Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing

Efficient immune responses rely on heterogeneity, which in CD8(+) T cells, amongst other mechanisms, is achieved by asymmetric cell division (ACD). Here we find that ageing, known to negatively impact immune responses, impairs ACD in murine CD8(+) T cells, and that this phenotype can be rescued by t...

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Detalles Bibliográficos
Autores principales: Borsa, Mariana, Barandun, Niculò, Gräbnitz, Fabienne, Barnstorf, Isabel, Baumann, Nicolas S., Pallmer, Katharina, Baumann, Samira, Stark, Dominique, Balaz, Miroslav, Oetiker, Nathalie, Wagen, Franziska, Wolfrum, Christian, Simon, Anna Katharina, Joller, Nicole, Barral, Yves, Spörri, Roman, Oxenius, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113513/
https://www.ncbi.nlm.nih.gov/pubmed/33976157
http://dx.doi.org/10.1038/s41467-021-22954-y

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