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Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines

Ebola virus (EBOV) glycoprotein (GP) can be recognized by neutralizing antibodies (NAbs) and is the main target for vaccine design. Here, we first investigate the contribution of the stalk and heptad repeat 1-C (HR1(C)) regions to GP metastability. Specific stalk and HR1(C) modifications in a mucin-...

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Detalles Bibliográficos
Autores principales:	He, Linling, Chaudhary, Anshul, Lin, Xiaohe, Sou, Cindy, Alkutkar, Tanwee, Kumar, Sonu, Ngo, Timothy, Kosviner, Ezra, Ozorowski, Gabriel, Stanfield, Robyn L., Ward, Andrew B., Wilson, Ian A., Zhu, Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113551/ https://www.ncbi.nlm.nih.gov/pubmed/33976149 http://dx.doi.org/10.1038/s41467-021-22867-w

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