Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation

N-Methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors essential for synaptic plasticity and memory. Receptor activation involves glycine- and glutamate-stabilized closure of the GluN1 and GluN2 subunit ligand binding domains that is allosterically regulated by the amino-terminal...

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Detalles Bibliográficos
Autores principales: Vyklicky, Vojtech, Stanley, Cherise, Habrian, Chris, Isacoff, Ehud Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113580/
https://www.ncbi.nlm.nih.gov/pubmed/33976221
http://dx.doi.org/10.1038/s41467-021-23024-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113580/
https://www.ncbi.nlm.nih.gov/pubmed/33976221
http://dx.doi.org/10.1038/s41467-021-23024-z

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