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Successful Radical Pneumonectomy for a Primitive Neuroendodermal Tumor in the Lung: A Case Report and Review of the Literature

Peripheral primitive neuroendodermal tumors (PNETs) and Ewing's sarcoma belong to the Ewing family of tumors and are small round-cell malignancies originating from spinal cord cells. These tumors account for 5% of all small round-cell malignant neoplasms. PNETs that arise from the lung parenchy...

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Autores principales: Yue, Bingqing, Chen, Peng, Yin, Pan, Wang, Jiankai, Liu, Fanying, Zhao, Duo, Chen, Jingyu, Jiang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113621/
https://www.ncbi.nlm.nih.gov/pubmed/33996888
http://dx.doi.org/10.3389/fsurg.2021.667467
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author Yue, Bingqing
Chen, Peng
Yin, Pan
Wang, Jiankai
Liu, Fanying
Zhao, Duo
Chen, Jingyu
Jiang, Hua
author_facet Yue, Bingqing
Chen, Peng
Yin, Pan
Wang, Jiankai
Liu, Fanying
Zhao, Duo
Chen, Jingyu
Jiang, Hua
author_sort Yue, Bingqing
collection PubMed
description Peripheral primitive neuroendodermal tumors (PNETs) and Ewing's sarcoma belong to the Ewing family of tumors and are small round-cell malignancies originating from spinal cord cells. These tumors account for 5% of all small round-cell malignant neoplasms. PNETs that arise from the lung parenchyma without pleural or chest wall involvement are very rare. We report a case of an adult female with a large pulmonary PNET who had given birth just 1 month prior to the diagnosis. She had cough and expectoration for 6 months, and the preoperative examination showed no metastases. Thus, we performed radical pneumonectomy and lymph node dissection. The patient recovered well without surgical complications and was discharged 7 days after the surgery. Postoperative pathology confirmed that the tumor was a small round-cell malignancy, and the tumor cells were positive for CD99, Friend leukemia virus integration 1 (FLI-1), and neuron-specific enolase (NSE), which was consistent with the diagnosis of a PNET. For primary large pulmonary PNETs, radical pneumonectomy may be a safe surgical method, worthy of further application in clinical practice.
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spelling pubmed-81136212021-05-13 Successful Radical Pneumonectomy for a Primitive Neuroendodermal Tumor in the Lung: A Case Report and Review of the Literature Yue, Bingqing Chen, Peng Yin, Pan Wang, Jiankai Liu, Fanying Zhao, Duo Chen, Jingyu Jiang, Hua Front Surg Surgery Peripheral primitive neuroendodermal tumors (PNETs) and Ewing's sarcoma belong to the Ewing family of tumors and are small round-cell malignancies originating from spinal cord cells. These tumors account for 5% of all small round-cell malignant neoplasms. PNETs that arise from the lung parenchyma without pleural or chest wall involvement are very rare. We report a case of an adult female with a large pulmonary PNET who had given birth just 1 month prior to the diagnosis. She had cough and expectoration for 6 months, and the preoperative examination showed no metastases. Thus, we performed radical pneumonectomy and lymph node dissection. The patient recovered well without surgical complications and was discharged 7 days after the surgery. Postoperative pathology confirmed that the tumor was a small round-cell malignancy, and the tumor cells were positive for CD99, Friend leukemia virus integration 1 (FLI-1), and neuron-specific enolase (NSE), which was consistent with the diagnosis of a PNET. For primary large pulmonary PNETs, radical pneumonectomy may be a safe surgical method, worthy of further application in clinical practice. Frontiers Media S.A. 2021-04-28 /pmc/articles/PMC8113621/ /pubmed/33996888 http://dx.doi.org/10.3389/fsurg.2021.667467 Text en Copyright © 2021 Yue, Chen, Yin, Wang, Liu, Zhao, Chen and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Yue, Bingqing
Chen, Peng
Yin, Pan
Wang, Jiankai
Liu, Fanying
Zhao, Duo
Chen, Jingyu
Jiang, Hua
Successful Radical Pneumonectomy for a Primitive Neuroendodermal Tumor in the Lung: A Case Report and Review of the Literature
title Successful Radical Pneumonectomy for a Primitive Neuroendodermal Tumor in the Lung: A Case Report and Review of the Literature
title_full Successful Radical Pneumonectomy for a Primitive Neuroendodermal Tumor in the Lung: A Case Report and Review of the Literature
title_fullStr Successful Radical Pneumonectomy for a Primitive Neuroendodermal Tumor in the Lung: A Case Report and Review of the Literature
title_full_unstemmed Successful Radical Pneumonectomy for a Primitive Neuroendodermal Tumor in the Lung: A Case Report and Review of the Literature
title_short Successful Radical Pneumonectomy for a Primitive Neuroendodermal Tumor in the Lung: A Case Report and Review of the Literature
title_sort successful radical pneumonectomy for a primitive neuroendodermal tumor in the lung: a case report and review of the literature
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113621/
https://www.ncbi.nlm.nih.gov/pubmed/33996888
http://dx.doi.org/10.3389/fsurg.2021.667467
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