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Valproic Acid Induces Autism-Like Synaptic and Behavioral Deficits by Disrupting Histone Acetylation of Prefrontal Cortex ALDH1A1 in Rats

OBJECTIVES: This study aimed to investigate the impact of valproic acid (VPA) on the histone acetylation of acetaldehyde dehydrogenase 1A1 (ALDH1A1) and the mechanism underlying VPA-induced autism-like behavior. METHODS: Female Sprague-Dawley rats were intraperitoneally injected with VPA during gest...

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Detalles Bibliográficos
Autores principales:	Liu, Huan, Tan, Mei, Cheng, Boli, Wang, Si, Xiao, Lu, Zhu, Jiang, Wu, Qionghui, Lai, Xi, Zhang, Qian, Chen, Jie, Li, Tingyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113628/ https://www.ncbi.nlm.nih.gov/pubmed/33994921 http://dx.doi.org/10.3389/fnins.2021.641284

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