Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction

Recombinant adeno-associated virus (rAAV) platforms hold promise for in vivo gene therapy but are undermined by the undesirable transduction of antigen presenting cells (APCs), which in turn can trigger host immunity towards rAAV-expressed transgene products. In light of recent adverse events in pat...

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Detalles Bibliográficos
Autores principales: Muhuri, Manish, Zhan, Wei, Maeda, Yukiko, Li, Jia, Lotun, Anoushka, Chen, Jennifer, Sylvia, Katelyn, Dasgupta, Ishani, Arjomandnejad, Motahareh, Nixon, Thomas, Keeler, Allison M., Manokaran, Sangeetha, He, Ran, Su, Qin, Tai, Phillip W. L., Gao, Guangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113644/
https://www.ncbi.nlm.nih.gov/pubmed/33995418
http://dx.doi.org/10.3389/fimmu.2021.674242

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