Cargando…
Amelioration of Endothelial Dysfunction in Diabetes: Role of Takeda G Protein–Coupled Receptor 5
Diabetes mellitus (DM) eventually leads to chronic vascular complications, resulting in cardiovascular diseases. DM-associated endothelial dysfunction (ED) plays an important role in the development of chronic vascular complications. Low endothelial nitric oxide synthase (eNOS) activity, inflammatio...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113688/ https://www.ncbi.nlm.nih.gov/pubmed/33995040 http://dx.doi.org/10.3389/fphar.2021.637051 |
_version_ | 1783690915284516864 |
---|---|
author | Cai, Zhengyao Yuan, Suxin Zhong, Yi Deng, Li Li, Jiafu Tan, Xiaoqiu Feng, Jian |
author_facet | Cai, Zhengyao Yuan, Suxin Zhong, Yi Deng, Li Li, Jiafu Tan, Xiaoqiu Feng, Jian |
author_sort | Cai, Zhengyao |
collection | PubMed |
description | Diabetes mellitus (DM) eventually leads to chronic vascular complications, resulting in cardiovascular diseases. DM-associated endothelial dysfunction (ED) plays an important role in the development of chronic vascular complications. Low endothelial nitric oxide synthase (eNOS) activity, inflammation, and oxidative stress all contribute to ED. The G protein–coupled receptor Takeda G protein–coupled receptor 5 (TGR5) is a membrane receptor for bile acids that plays an important role in the regulation of glucose metabolism. Recent studies have shown that TGR5 is involved in the regulation of various mediators of ED, which suggests that TGR5 may represent a target for the treatment of DM-associated ED. In this review, we summarize the principal mechanisms of DM-associated ED, then propose TGR5 as a novel therapeutic target on the basis of its mechanistic involvement, and suggest potential directions for future research. |
format | Online Article Text |
id | pubmed-8113688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81136882021-05-13 Amelioration of Endothelial Dysfunction in Diabetes: Role of Takeda G Protein–Coupled Receptor 5 Cai, Zhengyao Yuan, Suxin Zhong, Yi Deng, Li Li, Jiafu Tan, Xiaoqiu Feng, Jian Front Pharmacol Pharmacology Diabetes mellitus (DM) eventually leads to chronic vascular complications, resulting in cardiovascular diseases. DM-associated endothelial dysfunction (ED) plays an important role in the development of chronic vascular complications. Low endothelial nitric oxide synthase (eNOS) activity, inflammation, and oxidative stress all contribute to ED. The G protein–coupled receptor Takeda G protein–coupled receptor 5 (TGR5) is a membrane receptor for bile acids that plays an important role in the regulation of glucose metabolism. Recent studies have shown that TGR5 is involved in the regulation of various mediators of ED, which suggests that TGR5 may represent a target for the treatment of DM-associated ED. In this review, we summarize the principal mechanisms of DM-associated ED, then propose TGR5 as a novel therapeutic target on the basis of its mechanistic involvement, and suggest potential directions for future research. Frontiers Media S.A. 2021-04-28 /pmc/articles/PMC8113688/ /pubmed/33995040 http://dx.doi.org/10.3389/fphar.2021.637051 Text en Copyright © 2021 Cai, Yuan, Zhong, Deng, Li, Tan and Feng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Cai, Zhengyao Yuan, Suxin Zhong, Yi Deng, Li Li, Jiafu Tan, Xiaoqiu Feng, Jian Amelioration of Endothelial Dysfunction in Diabetes: Role of Takeda G Protein–Coupled Receptor 5 |
title | Amelioration of Endothelial Dysfunction in Diabetes: Role of Takeda G Protein–Coupled Receptor 5 |
title_full | Amelioration of Endothelial Dysfunction in Diabetes: Role of Takeda G Protein–Coupled Receptor 5 |
title_fullStr | Amelioration of Endothelial Dysfunction in Diabetes: Role of Takeda G Protein–Coupled Receptor 5 |
title_full_unstemmed | Amelioration of Endothelial Dysfunction in Diabetes: Role of Takeda G Protein–Coupled Receptor 5 |
title_short | Amelioration of Endothelial Dysfunction in Diabetes: Role of Takeda G Protein–Coupled Receptor 5 |
title_sort | amelioration of endothelial dysfunction in diabetes: role of takeda g protein–coupled receptor 5 |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113688/ https://www.ncbi.nlm.nih.gov/pubmed/33995040 http://dx.doi.org/10.3389/fphar.2021.637051 |
work_keys_str_mv | AT caizhengyao ameliorationofendothelialdysfunctionindiabetesroleoftakedagproteincoupledreceptor5 AT yuansuxin ameliorationofendothelialdysfunctionindiabetesroleoftakedagproteincoupledreceptor5 AT zhongyi ameliorationofendothelialdysfunctionindiabetesroleoftakedagproteincoupledreceptor5 AT dengli ameliorationofendothelialdysfunctionindiabetesroleoftakedagproteincoupledreceptor5 AT lijiafu ameliorationofendothelialdysfunctionindiabetesroleoftakedagproteincoupledreceptor5 AT tanxiaoqiu ameliorationofendothelialdysfunctionindiabetesroleoftakedagproteincoupledreceptor5 AT fengjian ameliorationofendothelialdysfunctionindiabetesroleoftakedagproteincoupledreceptor5 |