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Geographic Drivers of Antimicrobial Use and Resistance in Pigs in Khon Kaen Province, Thailand

In Thailand, pig production has increased considerably in the last decades to meet a growing demand for pork. Antimicrobials are used routinely in intensive pig production to treat infections and increase productivity. However, the use of antimicrobials also contributes to the rise of antimicrobial...

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Autores principales: Huber, Laura, Hallenberg, Gunilla Ström, Lunha, Kamonwan, Leangapichart, Thongpan, Jiwakanon, Jatesada, Hickman, Rachel A., Magnusson, Ulf, Sunde, Marianne, Järhult, Josef D., Van Boeckel, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113701/
https://www.ncbi.nlm.nih.gov/pubmed/33996982
http://dx.doi.org/10.3389/fvets.2021.659051
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author Huber, Laura
Hallenberg, Gunilla Ström
Lunha, Kamonwan
Leangapichart, Thongpan
Jiwakanon, Jatesada
Hickman, Rachel A.
Magnusson, Ulf
Sunde, Marianne
Järhult, Josef D.
Van Boeckel, Thomas P.
author_facet Huber, Laura
Hallenberg, Gunilla Ström
Lunha, Kamonwan
Leangapichart, Thongpan
Jiwakanon, Jatesada
Hickman, Rachel A.
Magnusson, Ulf
Sunde, Marianne
Järhult, Josef D.
Van Boeckel, Thomas P.
author_sort Huber, Laura
collection PubMed
description In Thailand, pig production has increased considerably in the last decades to meet a growing demand for pork. Antimicrobials are used routinely in intensive pig production to treat infections and increase productivity. However, the use of antimicrobials also contributes to the rise of antimicrobial resistance with potential consequences for animal and human health. Here, we quantify the association between antimicrobial use and resistance rates in extensive and intensive farms with a focus on geographic proximity between farm and drugstores. Of the 164 enrolled farms, 79% reported using antimicrobials for disease prevention, treatment, or as a feed additive. Antimicrobial-resistant E. coli were present in 63% of farms. These drugs included critically important antimicrobials, such as quinolones and penicillins. Medium-scale farms with intensive animal production practices showed higher resistance rates than small-scale farms with extensive practices. Farms with drug-resistant Escherichia coli were located closer to drugstores and a had a higher proportion of disease than farms without drug-resistant E. coli. We found no association between the presence of resistance in humans and antimicrobial use in pigs. Our findings call for actions to improve herd health to reduce the need for antimicrobials and systematic training of veterinarians and drugstore owners on judicious use of antimicrobials in animals to mitigate resistance.
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spelling pubmed-81137012021-05-13 Geographic Drivers of Antimicrobial Use and Resistance in Pigs in Khon Kaen Province, Thailand Huber, Laura Hallenberg, Gunilla Ström Lunha, Kamonwan Leangapichart, Thongpan Jiwakanon, Jatesada Hickman, Rachel A. Magnusson, Ulf Sunde, Marianne Järhult, Josef D. Van Boeckel, Thomas P. Front Vet Sci Veterinary Science In Thailand, pig production has increased considerably in the last decades to meet a growing demand for pork. Antimicrobials are used routinely in intensive pig production to treat infections and increase productivity. However, the use of antimicrobials also contributes to the rise of antimicrobial resistance with potential consequences for animal and human health. Here, we quantify the association between antimicrobial use and resistance rates in extensive and intensive farms with a focus on geographic proximity between farm and drugstores. Of the 164 enrolled farms, 79% reported using antimicrobials for disease prevention, treatment, or as a feed additive. Antimicrobial-resistant E. coli were present in 63% of farms. These drugs included critically important antimicrobials, such as quinolones and penicillins. Medium-scale farms with intensive animal production practices showed higher resistance rates than small-scale farms with extensive practices. Farms with drug-resistant Escherichia coli were located closer to drugstores and a had a higher proportion of disease than farms without drug-resistant E. coli. We found no association between the presence of resistance in humans and antimicrobial use in pigs. Our findings call for actions to improve herd health to reduce the need for antimicrobials and systematic training of veterinarians and drugstore owners on judicious use of antimicrobials in animals to mitigate resistance. Frontiers Media S.A. 2021-04-28 /pmc/articles/PMC8113701/ /pubmed/33996982 http://dx.doi.org/10.3389/fvets.2021.659051 Text en Copyright © 2021 Huber, Hallenberg, Lunha, Leangapichart, Jiwakanon, Hickman, Magnusson, Sunde, Järhult and Van Boeckel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Huber, Laura
Hallenberg, Gunilla Ström
Lunha, Kamonwan
Leangapichart, Thongpan
Jiwakanon, Jatesada
Hickman, Rachel A.
Magnusson, Ulf
Sunde, Marianne
Järhult, Josef D.
Van Boeckel, Thomas P.
Geographic Drivers of Antimicrobial Use and Resistance in Pigs in Khon Kaen Province, Thailand
title Geographic Drivers of Antimicrobial Use and Resistance in Pigs in Khon Kaen Province, Thailand
title_full Geographic Drivers of Antimicrobial Use and Resistance in Pigs in Khon Kaen Province, Thailand
title_fullStr Geographic Drivers of Antimicrobial Use and Resistance in Pigs in Khon Kaen Province, Thailand
title_full_unstemmed Geographic Drivers of Antimicrobial Use and Resistance in Pigs in Khon Kaen Province, Thailand
title_short Geographic Drivers of Antimicrobial Use and Resistance in Pigs in Khon Kaen Province, Thailand
title_sort geographic drivers of antimicrobial use and resistance in pigs in khon kaen province, thailand
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113701/
https://www.ncbi.nlm.nih.gov/pubmed/33996982
http://dx.doi.org/10.3389/fvets.2021.659051
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