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The proteomic data of liver in mice with hyperlipidemia

Fructus Rosae Roxburghii (FRR) has been considered as edible and medicinal fruit possessing antiatherosclerotic effect [1], [2], [3], [4], [5], but the mechanism is still unclear. Hyperlipidemia (HLP) is the material basis for atherosclerosis (AS) formation [6,7]. In this study, total cholesterol (T...

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Detalles Bibliográficos
Autores principales: Song, Pingping, Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113717/
https://www.ncbi.nlm.nih.gov/pubmed/34013003
http://dx.doi.org/10.1016/j.dib.2021.107050
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author Song, Pingping
Li, Jing
author_facet Song, Pingping
Li, Jing
author_sort Song, Pingping
collection PubMed
description Fructus Rosae Roxburghii (FRR) has been considered as edible and medicinal fruit possessing antiatherosclerotic effect [1], [2], [3], [4], [5], but the mechanism is still unclear. Hyperlipidemia (HLP) is the material basis for atherosclerosis (AS) formation [6,7]. In this study, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), lower high-density lipoprotein (HDL) and atherosclerotic index (ASI) in mice were analyzed under the action of FRR juice. Then differentially expressed proteins in liver were further analyzed by using TMT labeling and LC-MS/MS for better understanding the effect and molecular mechanism of FRR on diet-induced hyperlipidemic mice [8]. After the protein extraction and trypsin digestion, TMT labeling proteomic analysis were performed. The functions and KEGG signaling pathways of differentially expressed proteins were analyzed by bioinformatics methods. Hence, the potential antiatherosclerotic mechanism of FRR regulating blood lipids from protein level has great significance to explore new drug targets for AS.
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spelling pubmed-81137172021-05-18 The proteomic data of liver in mice with hyperlipidemia Song, Pingping Li, Jing Data Brief Data Article Fructus Rosae Roxburghii (FRR) has been considered as edible and medicinal fruit possessing antiatherosclerotic effect [1], [2], [3], [4], [5], but the mechanism is still unclear. Hyperlipidemia (HLP) is the material basis for atherosclerosis (AS) formation [6,7]. In this study, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), lower high-density lipoprotein (HDL) and atherosclerotic index (ASI) in mice were analyzed under the action of FRR juice. Then differentially expressed proteins in liver were further analyzed by using TMT labeling and LC-MS/MS for better understanding the effect and molecular mechanism of FRR on diet-induced hyperlipidemic mice [8]. After the protein extraction and trypsin digestion, TMT labeling proteomic analysis were performed. The functions and KEGG signaling pathways of differentially expressed proteins were analyzed by bioinformatics methods. Hence, the potential antiatherosclerotic mechanism of FRR regulating blood lipids from protein level has great significance to explore new drug targets for AS. Elsevier 2021-04-20 /pmc/articles/PMC8113717/ /pubmed/34013003 http://dx.doi.org/10.1016/j.dib.2021.107050 Text en © 2021 The Author(s). Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Data Article
Song, Pingping
Li, Jing
The proteomic data of liver in mice with hyperlipidemia
title The proteomic data of liver in mice with hyperlipidemia
title_full The proteomic data of liver in mice with hyperlipidemia
title_fullStr The proteomic data of liver in mice with hyperlipidemia
title_full_unstemmed The proteomic data of liver in mice with hyperlipidemia
title_short The proteomic data of liver in mice with hyperlipidemia
title_sort proteomic data of liver in mice with hyperlipidemia
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113717/
https://www.ncbi.nlm.nih.gov/pubmed/34013003
http://dx.doi.org/10.1016/j.dib.2021.107050
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