Cargando…
The proteomic data of liver in mice with hyperlipidemia
Fructus Rosae Roxburghii (FRR) has been considered as edible and medicinal fruit possessing antiatherosclerotic effect [1], [2], [3], [4], [5], but the mechanism is still unclear. Hyperlipidemia (HLP) is the material basis for atherosclerosis (AS) formation [6,7]. In this study, total cholesterol (T...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113717/ https://www.ncbi.nlm.nih.gov/pubmed/34013003 http://dx.doi.org/10.1016/j.dib.2021.107050 |
_version_ | 1783690922213507072 |
---|---|
author | Song, Pingping Li, Jing |
author_facet | Song, Pingping Li, Jing |
author_sort | Song, Pingping |
collection | PubMed |
description | Fructus Rosae Roxburghii (FRR) has been considered as edible and medicinal fruit possessing antiatherosclerotic effect [1], [2], [3], [4], [5], but the mechanism is still unclear. Hyperlipidemia (HLP) is the material basis for atherosclerosis (AS) formation [6,7]. In this study, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), lower high-density lipoprotein (HDL) and atherosclerotic index (ASI) in mice were analyzed under the action of FRR juice. Then differentially expressed proteins in liver were further analyzed by using TMT labeling and LC-MS/MS for better understanding the effect and molecular mechanism of FRR on diet-induced hyperlipidemic mice [8]. After the protein extraction and trypsin digestion, TMT labeling proteomic analysis were performed. The functions and KEGG signaling pathways of differentially expressed proteins were analyzed by bioinformatics methods. Hence, the potential antiatherosclerotic mechanism of FRR regulating blood lipids from protein level has great significance to explore new drug targets for AS. |
format | Online Article Text |
id | pubmed-8113717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81137172021-05-18 The proteomic data of liver in mice with hyperlipidemia Song, Pingping Li, Jing Data Brief Data Article Fructus Rosae Roxburghii (FRR) has been considered as edible and medicinal fruit possessing antiatherosclerotic effect [1], [2], [3], [4], [5], but the mechanism is still unclear. Hyperlipidemia (HLP) is the material basis for atherosclerosis (AS) formation [6,7]. In this study, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), lower high-density lipoprotein (HDL) and atherosclerotic index (ASI) in mice were analyzed under the action of FRR juice. Then differentially expressed proteins in liver were further analyzed by using TMT labeling and LC-MS/MS for better understanding the effect and molecular mechanism of FRR on diet-induced hyperlipidemic mice [8]. After the protein extraction and trypsin digestion, TMT labeling proteomic analysis were performed. The functions and KEGG signaling pathways of differentially expressed proteins were analyzed by bioinformatics methods. Hence, the potential antiatherosclerotic mechanism of FRR regulating blood lipids from protein level has great significance to explore new drug targets for AS. Elsevier 2021-04-20 /pmc/articles/PMC8113717/ /pubmed/34013003 http://dx.doi.org/10.1016/j.dib.2021.107050 Text en © 2021 The Author(s). Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Data Article Song, Pingping Li, Jing The proteomic data of liver in mice with hyperlipidemia |
title | The proteomic data of liver in mice with hyperlipidemia |
title_full | The proteomic data of liver in mice with hyperlipidemia |
title_fullStr | The proteomic data of liver in mice with hyperlipidemia |
title_full_unstemmed | The proteomic data of liver in mice with hyperlipidemia |
title_short | The proteomic data of liver in mice with hyperlipidemia |
title_sort | proteomic data of liver in mice with hyperlipidemia |
topic | Data Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113717/ https://www.ncbi.nlm.nih.gov/pubmed/34013003 http://dx.doi.org/10.1016/j.dib.2021.107050 |
work_keys_str_mv | AT songpingping theproteomicdataofliverinmicewithhyperlipidemia AT lijing theproteomicdataofliverinmicewithhyperlipidemia AT songpingping proteomicdataofliverinmicewithhyperlipidemia AT lijing proteomicdataofliverinmicewithhyperlipidemia |