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Structure–activity relationship of ipglycermide binding to phosphoglycerate mutases

Catalysis of human phosphoglycerate mutase is dependent on a 2,3-bisphosphoglycerate cofactor (dPGM), whereas the nonhomologous isozyme in many parasitic species is cofactor independent (iPGM). This mechanistic and phylogenetic diversity offers an opportunity for selective pharmacologic targeting of...

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Detalles Bibliográficos
Autores principales:	Wiedmann, Mareike, Dranchak, Patricia K., Aitha, Mahesh, Queme, Bryan, Collmus, Christopher D., Kashipathy, Maithri M., Kanter, Liza, Lamy, Laurence, Rogers, Joseph M., Tao, Dingyin, Battaile, Kevin P., Rai, Ganesha, Lovell, Scott, Suga, Hiroaki, Inglese, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113725/ https://www.ncbi.nlm.nih.gov/pubmed/33812994 http://dx.doi.org/10.1016/j.jbc.2021.100628

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