Amphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase

Interactions of membrane-bound mammalian cytochromes P450 (CYPs) with NADPH-cytochrome P450 oxidoreductase (POR), which are required for metabolism of xenobiotics, are facilitated by membrane lipids. A variety of membrane mimetics, such as phospholipid liposomes and nanodiscs, have been used to simu...

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Detalles Bibliográficos
Autores principales: Cheng, Shen, Bo, Zhiyuan, Hollenberg, Paul, Osawa, Yoichi, Zhang, Haoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113742/
https://www.ncbi.nlm.nih.gov/pubmed/33839156
http://dx.doi.org/10.1016/j.jbc.2021.100645

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