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A dynamic Dab2 keeps myosin VI stably on track

Myosins are actin-based motor proteins known to perform a variety of different mechanical tasks in cells including transporting cargo, generating tension, and linking the cytoskeleton and membrane. Myosins that function as transporters often form complexes with adaptor proteins and vesicular membran...

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Detalles Bibliográficos
Autores principales: Cirilo, Joseph A., Yengo, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113857/
https://www.ncbi.nlm.nih.gov/pubmed/34237899
http://dx.doi.org/10.1016/j.jbc.2021.100640
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author Cirilo, Joseph A.
Yengo, Christopher M.
author_facet Cirilo, Joseph A.
Yengo, Christopher M.
author_sort Cirilo, Joseph A.
collection PubMed
description Myosins are actin-based motor proteins known to perform a variety of different mechanical tasks in cells including transporting cargo, generating tension, and linking the cytoskeleton and membrane. Myosins that function as transporters often form complexes with adaptor proteins and vesicular membranes, making it unclear how they transport their cargo through the actin cytoskeletal network. Rai et al. now use single-molecule kinetics, FRET, and DNA origami scaffolds that mimic motor–adaptor complexes to reveal that the myosin VI-Dab2 complex, which is held together weakly and turns over rapidly, can facilitate processive transport without disruption of the cytoskeleton.
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spelling pubmed-81138572021-05-18 A dynamic Dab2 keeps myosin VI stably on track Cirilo, Joseph A. Yengo, Christopher M. J Biol Chem Editors' Pick Highlight Myosins are actin-based motor proteins known to perform a variety of different mechanical tasks in cells including transporting cargo, generating tension, and linking the cytoskeleton and membrane. Myosins that function as transporters often form complexes with adaptor proteins and vesicular membranes, making it unclear how they transport their cargo through the actin cytoskeletal network. Rai et al. now use single-molecule kinetics, FRET, and DNA origami scaffolds that mimic motor–adaptor complexes to reveal that the myosin VI-Dab2 complex, which is held together weakly and turns over rapidly, can facilitate processive transport without disruption of the cytoskeleton. American Society for Biochemistry and Molecular Biology 2021-05-03 /pmc/articles/PMC8113857/ /pubmed/34237899 http://dx.doi.org/10.1016/j.jbc.2021.100640 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editors' Pick Highlight
Cirilo, Joseph A.
Yengo, Christopher M.
A dynamic Dab2 keeps myosin VI stably on track
title A dynamic Dab2 keeps myosin VI stably on track
title_full A dynamic Dab2 keeps myosin VI stably on track
title_fullStr A dynamic Dab2 keeps myosin VI stably on track
title_full_unstemmed A dynamic Dab2 keeps myosin VI stably on track
title_short A dynamic Dab2 keeps myosin VI stably on track
title_sort dynamic dab2 keeps myosin vi stably on track
topic Editors' Pick Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113857/
https://www.ncbi.nlm.nih.gov/pubmed/34237899
http://dx.doi.org/10.1016/j.jbc.2021.100640
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