Cargando…

Molecular properties of human guanylate cyclase–activating protein 2 (GCAP2) and its retinal dystrophy–associated variant G157R

In murine and bovine photoreceptors, guanylate cyclase–activating protein 2 (GCAP2) activates retinal guanylate cyclases (GCs) at low Ca(2+) levels, thus contributing to the Ca(2+)/cGMP negative feedback on the cyclase together with its paralog guanylate cyclase–activating protein 1, which has the s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Avesani, Anna, Marino, Valerio, Zanzoni, Serena, Koch, Karl-Wilhelm, Dell'Orco, Daniele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113879/ https://www.ncbi.nlm.nih.gov/pubmed/33812995 http://dx.doi.org/10.1016/j.jbc.2021.100619

Ejemplares similares

Molecular Properties of Human Guanylate Cyclase-Activating Protein 3 (GCAP3) and Its Possible Association with Retinitis Pigmentosa
por: Avesani, Anna, et al.
Publicado: (2022)

Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to “Locking” Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition
por: Abbas, Seher, et al.
Publicado: (2020)

Modulation of Guanylate Cyclase Activating Protein 1 (GCAP1) Dimeric Assembly by Ca(2+) or Mg(2+): Hints to Understand Protein Activity
por: Bonì, Francesco, et al.
Publicado: (2020)

Allosteric communication pathways routed by Ca(2+)/Mg(2+) exchange in GCAP1 selectively switch target regulation modes
por: Marino, Valerio, et al.
Publicado: (2016)

Normal GCAPs partly compensate for altered cGMP signaling in retinal dystrophies associated with mutations in GUCA1A
por: Dell’Orco, Daniele, et al.
Publicado: (2019)

Structural Insights for Activation of Retinal Guanylate Cyclase by GCAP1
por: Lim, Sunghyuk, et al.
Publicado: (2013)

Structural Insights into Retinal Guanylate Cyclase Activator Proteins (GCAPs)
por: Ames, James B.
Publicado: (2021)

A Novel GUCA1A Variant Associated with Cone Dystrophy Alters cGMP Signaling in Photoreceptors by Strongly Interacting with and Hyperactivating Retinal Guanylate Cyclase
por: Biasi, Amedeo, et al.
Publicado: (2021)

Structural basis of retinal membrane guanylate cyclase regulation by GCAP1 and RD3
por: Ames, James B.
Publicado: (2022)

Impaired Ca(2+) Sensitivity of a Novel GCAP1 Variant Causes Cone Dystrophy and Leads to Abnormal Synaptic Transmission Between Photoreceptors and Bipolar Cells
por: Marino, Valerio, et al.
Publicado: (2021)

Molecular Details of Retinal Guanylyl Cyclase 1/GCAP-2 Interaction
por: Rehkamp, Anne, et al.
Publicado: (2018)

Bringing the Ca(2+) sensitivity of myristoylated recoverin into the physiological range
por: Marino, Valerio, et al.
Publicado: (2021)

Photoreceptor Guanylate Cyclase (GUCY2D) Mutations Cause Retinal Dystrophies by Severe Malfunction of Ca(2+)-Dependent Cyclic GMP Synthesis
por: Wimberg, Hanna, et al.
Publicado: (2018)

Dysfunction of outer segment guanylate cyclase caused by retinal disease related mutations
por: Zägel, Patrick, et al.
Publicado: (2014)

Interaction of GCAP1 with retinal guanylyl cyclase and calcium: sensitivity to fatty acylation
por: Peshenko, Igor V., et al.
Publicado: (2012)

Retinal degeneration protein 3 controls membrane guanylate cyclase activities in brain tissue
por: Chen, Yaoyu, et al.
Publicado: (2022)

Biallelic Variants in TULP1 Are Associated with Heterogeneous Phenotypes of Retinal Dystrophy
por: Bodenbender, Jan-Philipp, et al.
Publicado: (2023)

Evolutionary-Conserved Allosteric Properties of Three Neuronal Calcium Sensor Proteins
por: Marino, Valerio, et al.
Publicado: (2019)

Protein and Signaling Networks in Vertebrate Photoreceptor Cells
por: Koch, Karl-Wilhelm, et al.
Publicado: (2015)

Zebrafish Guanylate Cyclase Type 3 Signaling in Cone Photoreceptors
por: Fries, Ramona, et al.
Publicado: (2013)

Structural diversity of neuronal calcium sensor proteins and insights for activation of retinal guanylyl cyclase by GCAP1
por: Lim, Sunghyuk, et al.
Publicado: (2014)

Recombinant protein delivery enables modulation of the phototransduction cascade in mouse retina
por: Asteriti, Sabrina, et al.
Publicado: (2023)

The Transition of Photoreceptor Guanylate Cyclase Type 1 to the Active State
por: Shahu, Manisha Kumari, et al.
Publicado: (2022)

Where vision begins
por: Dell’Orco, Daniele, et al.
Publicado: (2021)

Reanalysis of Association of Pro50Leu Substitution in Guanylate Cyclase Activating Protein-1 With Dominant Retinal Dystrophy
por: Mahroo, Omar A., et al.
Publicado: (2020)

Differential Calcium Signaling by Cone Specific Guanylate Cyclase-Activating Proteins from the Zebrafish Retina
por: Scholten, Alexander, et al.
Publicado: (2011)

Characterization of guanylate cyclase activity in single retinal rod outer segments
Publicado: (1995)

Calcium- and Integrin-Binding Protein 2 (CIB2) in Physiology and Disease: Bright and Dark Sides
por: Dal Cortivo, Giuditta, et al.
Publicado: (2022)

Calmodulin variants associated with congenital arrhythmia impair selectivity for ryanodine receptors
por: Dal Cortivo, Giuditta, et al.
Publicado: (2023)

Structural studies of soluble guanylate cyclase
por: Macdonald, Jane, et al.
Publicado: (2009)

Chemical shift assignments of retinal guanylyl cyclase activating protein 5 (GCAP5) with a mutation (R22A) that abolishes dimerization and enhances cyclase activation
por: Cudia, Diana, et al.
Publicado: (2023)

Effects of Membrane and Biological Target on the Structural and Allosteric Properties of Recoverin: A Computational Approach
por: Borsatto, Alberto, et al.
Publicado: (2019)

Retina specific GCAPs in zebrafish acquire functional selectivity in Ca(2+)-sensing by myristoylation and Mg(2+)-binding
por: Sulmann, Stefan, et al.
Publicado: (2015)

Label-free quantification of calcium-sensor targeting to photoreceptor guanylate cyclase and rhodopsin kinase by backscattering interferometry
por: Sulmann, Stefan, et al.
Publicado: (2017)

Soluble Guanylate Cyclase Stimulators in Heart Failure
por: Kansakar, Sajog, et al.
Publicado: (2021)

Erratum: Retina specific GCAPs in zebrafish acquire functional selectivity in Ca(2+)-sensing by myristoylation and Mg(2+)-binding
por: Sulmann, Stefan, et al.
Publicado: (2015)

Autosomal Dominant Gyrate Atrophy-Like Choroidal Dystrophy Revisited: 45 Years Follow-Up and Association with a Novel C1QTNF5 Missense Variant
por: Kellner, Ulrich, et al.
Publicado: (2021)

Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling
por: Invergo, Brandon M, et al.
Publicado: (2013)

A hybrid stochastic/deterministic model of single photon response and light adaptation in mouse rods
por: Beelen, Charlotte Johanna, et al.
Publicado: (2021)

Network and Atomistic Simulations Unveil the Structural Determinants of Mutations Linked to Retinal Diseases
por: Mariani, Simona, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_pnfrcu2so0rb518d6l95ukt3mp