Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease

Translocator protein (TSPO, 18 kDa) levels increase in parallel with the evolution of simple steatosis (SS) to nonalcoholic steatohepatitis (NASH) in nonalcoholic fatty liver disease (NAFLD). However, TSPO function in SS and NASH is unknown. Loss of TSPO in hepatocytes in vitro downregulated acetyl-...

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Detalles Bibliográficos
Autores principales: Li, Yuchang, Chen, Liting, Li, Lu, Sottas, Chantal, Petrillo, Stephanie K., Lazaris, Anthoula, Metrakos, Peter, Wu, Hangyu, Ishida, Yuji, Saito, Takeshi, Golden-Mason, Lucy, Rosen, Hugo R., Wolff, Jeremy J., Silvescu, Cristina I., Garza, Samuel, Cheung, Garett, Huang, Tiffany, Fan, Jinjiang, Culty, Martine, Stiles, Bangyan, Asahina, Kinji, Papadopoulos, Vassilios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113880/
https://www.ncbi.nlm.nih.gov/pubmed/34013171
http://dx.doi.org/10.1016/j.isci.2021.102457

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