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The C99 domain of the amyloid precursor protein resides in the disordered membrane phase

Processing of the amyloid precursor protein (APP) via the amyloidogenic pathway is associated with the etiology of Alzheimer’s disease. The cleavage of APP by β-secretase to generate the transmembrane 99-residue C-terminal fragment (C99) and subsequent processing of C99 by γ-secretase to yield amylo...

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Detalles Bibliográficos
Autores principales:	Capone, Ricardo, Tiwari, Ajit, Hadziselimovic, Arina, Peskova, Yelena, Hutchison, James M., Sanders, Charles R., Kenworthy, Anne K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113881/ https://www.ncbi.nlm.nih.gov/pubmed/33839158 http://dx.doi.org/10.1016/j.jbc.2021.100652

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