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Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation

TREM2 is a pattern recognition receptor, expressed on microglia and myeloid cells, detecting lipids and Aβ and inducing an innate immune response. Missense mutations (e.g., R47H) of TREM2 increase risk of Alzheimer's disease (AD). The soluble ectodomain of wild-type TREM2 (sTREM2) has been show...

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Detalles Bibliográficos
Autores principales:	Vilalta, Anna, Zhou, Ye, Sevalle, Jean, Griffin, Jennifer K., Satoh, Kanayo, Allendorf, David H., De, Suman, Puigdellívol, Mar, Bruzas, Arturas, Burguillos, Miguel A., Dodd, Roger B., Chen, Fusheng, Zhang, Yalun, Flagmeier, Patrick, Needham, Lisa-Maria, Enomoto, Masahiro, Qamar, Seema, Henderson, James, Walter, Jochen, Fraser, Paul E., Klenerman, David, Lee, Steven F., St George-Hyslop, Peter, Brown, Guy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113883/ https://www.ncbi.nlm.nih.gov/pubmed/33823153 http://dx.doi.org/10.1016/j.jbc.2021.100631

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