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The Interaction of Insulin and Pituitary Hormone Syndromes
Pituitary hormone axes modulate glucose metabolism and exert direct or indirect effects on insulin secretion and function. Cortisol and growth hormone are potent insulin-antagonistic hormones. Therefore impaired glucose tolerance, elevated fasting glucose concentrations and diabetes mellitus are fre...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113952/ https://www.ncbi.nlm.nih.gov/pubmed/33995272 http://dx.doi.org/10.3389/fendo.2021.626427 |
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author | Schernthaner-Reiter, Marie Helene Wolf, Peter Vila, Greisa Luger, Anton |
author_facet | Schernthaner-Reiter, Marie Helene Wolf, Peter Vila, Greisa Luger, Anton |
author_sort | Schernthaner-Reiter, Marie Helene |
collection | PubMed |
description | Pituitary hormone axes modulate glucose metabolism and exert direct or indirect effects on insulin secretion and function. Cortisol and growth hormone are potent insulin-antagonistic hormones. Therefore impaired glucose tolerance, elevated fasting glucose concentrations and diabetes mellitus are frequent in Cushing’s disease and acromegaly. Also prolactinomas, growth hormone (GH) deficiency, hypogonadism and hypothyroidism might be associated with impaired glucose homeostasis but usually to a lesser extent. Therefore glucose metabolism needs to be closely monitored and treated in patients with pituitary adenomas. Correction of the pituitary dysfunction is frequently followed by improvement of glucose homeostasis. |
format | Online Article Text |
id | pubmed-8113952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81139522021-05-13 The Interaction of Insulin and Pituitary Hormone Syndromes Schernthaner-Reiter, Marie Helene Wolf, Peter Vila, Greisa Luger, Anton Front Endocrinol (Lausanne) Endocrinology Pituitary hormone axes modulate glucose metabolism and exert direct or indirect effects on insulin secretion and function. Cortisol and growth hormone are potent insulin-antagonistic hormones. Therefore impaired glucose tolerance, elevated fasting glucose concentrations and diabetes mellitus are frequent in Cushing’s disease and acromegaly. Also prolactinomas, growth hormone (GH) deficiency, hypogonadism and hypothyroidism might be associated with impaired glucose homeostasis but usually to a lesser extent. Therefore glucose metabolism needs to be closely monitored and treated in patients with pituitary adenomas. Correction of the pituitary dysfunction is frequently followed by improvement of glucose homeostasis. Frontiers Media S.A. 2021-04-28 /pmc/articles/PMC8113952/ /pubmed/33995272 http://dx.doi.org/10.3389/fendo.2021.626427 Text en Copyright © 2021 Schernthaner-Reiter, Wolf, Vila and Luger https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Schernthaner-Reiter, Marie Helene Wolf, Peter Vila, Greisa Luger, Anton The Interaction of Insulin and Pituitary Hormone Syndromes |
title | The Interaction of Insulin and Pituitary Hormone Syndromes |
title_full | The Interaction of Insulin and Pituitary Hormone Syndromes |
title_fullStr | The Interaction of Insulin and Pituitary Hormone Syndromes |
title_full_unstemmed | The Interaction of Insulin and Pituitary Hormone Syndromes |
title_short | The Interaction of Insulin and Pituitary Hormone Syndromes |
title_sort | interaction of insulin and pituitary hormone syndromes |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113952/ https://www.ncbi.nlm.nih.gov/pubmed/33995272 http://dx.doi.org/10.3389/fendo.2021.626427 |
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