Mechanism of recognition of parallel G-quadruplexes by DEAH/RHAU helicase DHX36 explored by molecular dynamics simulations

Because of high stability and slow unfolding rates of G-quadruplexes (G4), cells have evolved specialized helicases that disrupt these non-canonical DNA and RNA structures in an ATP-dependent manner. One example is DHX36, a DEAH-box helicase, which participates in gene expression and replication by...

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Detalles Bibliográficos
Autores principales: Hossain, Kazi Amirul, Jurkowski, Michal, Czub, Jacek, Kogut, Mateusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114077/
https://www.ncbi.nlm.nih.gov/pubmed/34025941
http://dx.doi.org/10.1016/j.csbj.2021.04.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114077/
https://www.ncbi.nlm.nih.gov/pubmed/34025941
http://dx.doi.org/10.1016/j.csbj.2021.04.039

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