Cargando…

Population Pharmacokinetics and Initial Dose Optimization of Sirolimus Improving Drug Blood Level for Seizure Control in Pediatric Patients With Tuberous Sclerosis Complex

The purposes of this study were to explore the population pharmacokinetics and initial dose optimization of sirolimus improving drug blood level for seizure control in pediatric patients with tuberous sclerosis complex (TSC). Eighty pediatric patients diagnosed with TSC-related epilepsy were include...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Xiao, Wang, Dongdong, Zhu, Lin, Lu, Jinmiao, Huang, Yidie, Wang, Guangfei, Zhu, Yiqing, Ye, Qiaofeng, Wang, Yi, Xu, Hong, Li, Zhiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114543/ https://www.ncbi.nlm.nih.gov/pubmed/33995061 http://dx.doi.org/10.3389/fphar.2021.647232

Ejemplares similares

Optimization of Initial Dose Regimen for Sirolimus in Pediatric Patients With Lymphangioma
por: Chen, Xiao, et al.
Publicado: (2021)

Initial Dosage Recommendation for Sirolimus in Children With Tuberous Sclerosis Complex
por: Wang, Dong-Dong, et al.
Publicado: (2020)

Effects of Posaconazole on Tacrolimus Population Pharmacokinetics and Initial Dose in Children With Crohn’s Disease Undergoing Hematopoietic Stem Cell Transplantation
por: Chen, Xiao, et al.
Publicado: (2022)

Population Pharmacokinetics of Enteric-Coated Mycophenolate Sodium in Children after Renal Transplantation and Initial Dosage Recommendation Based on Body Surface Area
por: Wang, Guangfei, et al.
Publicado: (2022)

Population pharmacokinetics of sirolimus in pediatric patients with kaposiform hemangioendothelioma: A retrospective study
por: Wang, Dongdong, et al.
Publicado: (2019)

Initial sirolimus dosage recommendations for pediatric patients with PIK3CD mutation-related immunodeficiency disease
por: Chen, Xiao, et al.
Publicado: (2022)

Optimized Dosing Regimens of Meropenem in Septic Children Receiving Extracorporeal Life Support
por: Wang, Yixue, et al.
Publicado: (2021)

Mycophenolic Acid Exposure Optimization Based on Vitamin D Status in Children with Systemic Lupus Erythematosus: A Single-Center Retrospective Study
por: Ye, Qiaofeng, et al.
Publicado: (2021)

Population pharmacokinetics and initial dose optimization of tacrolimus in children with severe combined immunodeficiency undergoing hematopoietic stem cell transplantation
por: Chen, Xiao, et al.
Publicado: (2022)

Population pharmacokinetics of tacrolimus in pediatric refractory nephrotic syndrome and a summary of other pediatric disease models
por: Wang, Dongdong, et al.
Publicado: (2019)

Sirolimus Ointment for Facial Angiofibromas in Individuals with Tuberous Sclerosis Complex
por: Amin, S., et al.
Publicado: (2017)

Low-dose oral hydroxychloroquine led to impaired vision in a child with renal failure: Case report and literature review
por: Lu, Jinmiao, et al.
Publicado: (2021)

Facial Angiofibromas of Tuberous Sclerosis Treated with Topical Sirolimus in an Indian Patient
por: Vasani, Resham J
Publicado: (2015)

Sirolimus in Infants with Multiple Cardiac Rhabdomyomas Associated with Tuberous Sclerosis Complex
por: Lucchesi, Maurizio, et al.
Publicado: (2018)

Effects of voriconazole on population pharmacokinetics and optimization of the initial dose of tacrolimus in children with chronic granulomatous disease undergoing hematopoietic stem cell transplantation
por: Chen, Xiao, et al.
Publicado: (2021)

Sirolimus therapy for fetal cardiac rhabdomyoma in a pregnant woman with tuberous sclerosis
por: Park, Hyea, et al.
Publicado: (2019)

Seizure Localization in Patients with Multiple Tubers: Presurgical Evaluation in Tuberous Sclerosis
por: Song, Pamela, et al.
Publicado: (2012)

MicroRNA-221-3p Suppresses the Microglia Activation and Seizures by Inhibiting of HIF-1α in Valproic Acid-Resistant Epilepsy
por: Fu, Meng, et al.
Publicado: (2021)

Transcriptomics analysis of sirolimus treatment in lupus nephritis
por: Wang, Dongdong, et al.
Publicado: (2019)

Everolimus dosing recommendations for tuberous sclerosis complex–associated refractory seizures
por: Franz, David N., et al.
Publicado: (2018)

Clinical features and antimicrobial susceptibility profiles of culture-proven neonatal sepsis in a tertiary children's hospital, 2013 to 2017
por: Li, Xiaoxia, et al.
Publicado: (2019)

Long-term efficacy and safety of sirolimus for retinal astrocytic hamartoma associated with tuberous sclerosis complex
por: Zhang, Chen-Xi, et al.
Publicado: (2022)

Initial dose recommendation for sirolimus in paediatric kaposiform haemangioendothelioma patients based on population pharmacokinetics and pharmacogenomics
por: Chen, Xiao, et al.
Publicado: (2020)

Population Pharmacokinetics of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia
por: Gao, Xuan, et al.
Publicado: (2021)

Population Pharmacokinetics and Initial Dosage Optimization of Tacrolimus in Pediatric Hematopoietic Stem Cell Transplant Patients
por: Liu, Xiao-Lin, et al.
Publicado: (2022)

Population pharmacokinetics of tacrolimus in pediatric patients with systemic-onset juvenile idiopathic arthritis: Initial dosage recommendations
por: Wang, Dongdong, et al.
Publicado: (2019)

Precision sirolimus dosing in children: The potential for model-informed dosing and novel drug monitoring
por: Shen, Guofang, et al.
Publicado: (2023)

Optimal management of seizures associated with tuberous sclerosis complex: current and emerging options
por: Wang, Shelly, et al.
Publicado: (2014)

Population Pharmacokinetics and Model-Based Dosing Optimization of Teicoplanin in Pediatric Patients
por: Zhang, Tao, et al.
Publicado: (2020)

Population Pharmacokinetics of Rituximab in Pediatric Patients With Frequent-Relapsing or Steroid-Dependent Nephrotic Syndrome
por: Chen, Yewei, et al.
Publicado: (2021)

All tubers are not created equal: Cerebellar tubers in a pediatric patient with tuberous sclerosis
por: Weerasinghe, Sanjeeva, et al.
Publicado: (2020)

Early Sirolimus Gel Treatment May Diminish Angiofibromas and Prevent Angiofibroma Recurrence in Children With Tuberous Sclerosis Complex
por: Okanishi, Tohru, et al.
Publicado: (2020)

Everolimus versus sirolimus for angiomyolipoma associated with tuberous sclerosis complex: a multi-institutional retrospective study in China
por: Luo, Cong, et al.
Publicado: (2021)

Sirolimus-Induced Regression of Tuberous Sclerosis–Associated Cardiac Rhabdomyoma Causing Left Ventricular Outflow Tract Obstruction
por: Winkie, Colin, et al.
Publicado: (2022)

Safety of Sirolimus in Patients with Tuberous Sclerosis Complex under Two Years of Age—A Bicenter Retrospective Study
por: Śmiałek, Dominika, et al.
Publicado: (2023)

Population Pharmacokinetics of Cyclosporine in Chinese Pediatric Patients With Acquired Aplastic Anemia
por: Gao, Xuan, et al.
Publicado: (2022)

Population Pharmacokinetics of Lithium in Young Pediatric Patients With Intellectual Disability
por: Yuan, Junying, et al.
Publicado: (2021)

Clinical seizure semiology is subtle and identification of seizures by parents is unreliable in infants with tuberous sclerosis complex
por: Lynch, Matthew, et al.
Publicado: (2022)

Improved health-related quality of life in patients treated with topical sirolimus for facial angiofibroma associated with tuberous sclerosis complex
por: Hatano, Takashi, et al.
Publicado: (2020)

Molecular Mechanism of YuPingFeng in the Treatment of Asthma Based on Network Pharmacology and Molecular Docking Technology
por: Shen, Li, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8uqj9iih8gf7sdn6oedjkb2dmr