An NTD supersite of attack

To date, most antibodies recognizing the SARS-CoV-2 spike (S) protein target the receptor binding domain (RBD). Three recent studies (Cerutti et al., 2021; McCallum et al., 2021; and Suryadevara et al., 2021) report on highly protective antibodies that are specific to the N-terminal domain (NTD) and...

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Autor principal: Lok, Shee-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114578/
https://www.ncbi.nlm.nih.gov/pubmed/33984277
http://dx.doi.org/10.1016/j.chom.2021.04.010
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author Lok, Shee-Mei
author_facet Lok, Shee-Mei
author_sort Lok, Shee-Mei
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description To date, most antibodies recognizing the SARS-CoV-2 spike (S) protein target the receptor binding domain (RBD). Three recent studies (Cerutti et al., 2021; McCallum et al., 2021; and Suryadevara et al., 2021) report on highly protective antibodies that are specific to the N-terminal domain (NTD) and target a conserved supersite.
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spelling pubmed-81145782021-05-12 An NTD supersite of attack Lok, Shee-Mei Cell Host Microbe Preview To date, most antibodies recognizing the SARS-CoV-2 spike (S) protein target the receptor binding domain (RBD). Three recent studies (Cerutti et al., 2021; McCallum et al., 2021; and Suryadevara et al., 2021) report on highly protective antibodies that are specific to the N-terminal domain (NTD) and target a conserved supersite. Elsevier Inc. 2021-05-12 2021-05-12 /pmc/articles/PMC8114578/ /pubmed/33984277 http://dx.doi.org/10.1016/j.chom.2021.04.010 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Preview
Lok, Shee-Mei
An NTD supersite of attack
title An NTD supersite of attack
title_full An NTD supersite of attack
title_fullStr An NTD supersite of attack
title_full_unstemmed An NTD supersite of attack
title_short An NTD supersite of attack
title_sort ntd supersite of attack
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114578/
https://www.ncbi.nlm.nih.gov/pubmed/33984277
http://dx.doi.org/10.1016/j.chom.2021.04.010
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