Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion

BACKGROUND: EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling pathways and epithelial-to-mesenchymal transition. It was recently demonstrated that EpCAM contains a thyroglobulin type-1 (TY-1)...

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Detalles Bibliográficos
Autores principales: Sankpal, Narendra V., Brown, Taylor C., Fleming, Timothy P., Herndon, John M., Amaravati, Anusha A., Loynd, Allison N., Gillanders, William E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114703/
https://www.ncbi.nlm.nih.gov/pubmed/33980181
http://dx.doi.org/10.1186/s12885-021-08239-z

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