Insights into the endoscopic management of esophageal achalasia

Achalasia is a primary esophageal motility disorder characterized by the loss of inhibitory neurons in the myenteric plexus, resulting in impaired relaxation of the esophagogastric junction. Achalasia is an incurable disease, and the treatment modalities are aimed at disruption of the esophagogastri...

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Detalles Bibliográficos
Autores principales: Brindise, Elizabeth, Khashab, Mouen A., El Abiad, Rami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114742/
https://www.ncbi.nlm.nih.gov/pubmed/34017943
http://dx.doi.org/10.1177/26317745211014706
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author Brindise, Elizabeth
Khashab, Mouen A.
El Abiad, Rami
author_facet Brindise, Elizabeth
Khashab, Mouen A.
El Abiad, Rami
author_sort Brindise, Elizabeth
collection PubMed
description Achalasia is a primary esophageal motility disorder characterized by the loss of inhibitory neurons in the myenteric plexus, resulting in impaired relaxation of the esophagogastric junction. Achalasia is an incurable disease, and the treatment modalities are aimed at disruption of the esophagogastric junction and vary widely from pharmacological to endoscopic to surgical. Traditional endoscopic therapy includes pneumatic dilation, botulinum toxin injection, and peroral endoscopic myotomy. This review aims to provide an overview of the endoscopic management of achalasia, while focusing on the utilization of peroral endoscopic myotomy and other novel approaches.
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spelling pubmed-81147422021-05-19 Insights into the endoscopic management of esophageal achalasia Brindise, Elizabeth Khashab, Mouen A. El Abiad, Rami Ther Adv Gastrointest Endosc Review Achalasia is a primary esophageal motility disorder characterized by the loss of inhibitory neurons in the myenteric plexus, resulting in impaired relaxation of the esophagogastric junction. Achalasia is an incurable disease, and the treatment modalities are aimed at disruption of the esophagogastric junction and vary widely from pharmacological to endoscopic to surgical. Traditional endoscopic therapy includes pneumatic dilation, botulinum toxin injection, and peroral endoscopic myotomy. This review aims to provide an overview of the endoscopic management of achalasia, while focusing on the utilization of peroral endoscopic myotomy and other novel approaches. SAGE Publications 2021-05-05 /pmc/articles/PMC8114742/ /pubmed/34017943 http://dx.doi.org/10.1177/26317745211014706 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Brindise, Elizabeth
Khashab, Mouen A.
El Abiad, Rami
Insights into the endoscopic management of esophageal achalasia
title Insights into the endoscopic management of esophageal achalasia
title_full Insights into the endoscopic management of esophageal achalasia
title_fullStr Insights into the endoscopic management of esophageal achalasia
title_full_unstemmed Insights into the endoscopic management of esophageal achalasia
title_short Insights into the endoscopic management of esophageal achalasia
title_sort insights into the endoscopic management of esophageal achalasia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114742/
https://www.ncbi.nlm.nih.gov/pubmed/34017943
http://dx.doi.org/10.1177/26317745211014706
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