Cargando…
Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells
Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcr...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Neuroscience Society
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114861/ https://www.ncbi.nlm.nih.gov/pubmed/33995925 http://dx.doi.org/10.32598/bcn.9.10.510 |
_version_ | 1783691133358964736 |
---|---|
author | Kadkhodaeian, Hamid Aboutaleb |
author_facet | Kadkhodaeian, Hamid Aboutaleb |
author_sort | Kadkhodaeian, Hamid Aboutaleb |
collection | PubMed |
description | Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcription factors required for retinal progenitor cells are well known, but the generation of these cells from mesenchymal stem cells is an ideal goal. The purpose of the paper is to review novel methods for retinal progenitor cell production and selecting a set of signaling molecules in the presence of adult retinal pigment epithelium and extraocular mesenchyme acting as inducers of retinal cell differentiation. |
format | Online Article Text |
id | pubmed-8114861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Iranian Neuroscience Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-81148612021-05-14 Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells Kadkhodaeian, Hamid Aboutaleb Basic Clin Neurosci Review Paper Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcription factors required for retinal progenitor cells are well known, but the generation of these cells from mesenchymal stem cells is an ideal goal. The purpose of the paper is to review novel methods for retinal progenitor cell production and selecting a set of signaling molecules in the presence of adult retinal pigment epithelium and extraocular mesenchyme acting as inducers of retinal cell differentiation. Iranian Neuroscience Society 2021 2021-01-01 /pmc/articles/PMC8114861/ /pubmed/33995925 http://dx.doi.org/10.32598/bcn.9.10.510 Text en Copyright© 2021 Iranian Neuroscience Society https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Review Paper Kadkhodaeian, Hamid Aboutaleb Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells |
title | Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells |
title_full | Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells |
title_fullStr | Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells |
title_full_unstemmed | Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells |
title_short | Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells |
title_sort | mesenchymal stem cells: signaling pathways in transdifferentiation into retinal progenitor cells |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114861/ https://www.ncbi.nlm.nih.gov/pubmed/33995925 http://dx.doi.org/10.32598/bcn.9.10.510 |
work_keys_str_mv | AT kadkhodaeianhamidaboutaleb mesenchymalstemcellssignalingpathwaysintransdifferentiationintoretinalprogenitorcells |