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Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells

Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcr...

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Autor principal: Kadkhodaeian, Hamid Aboutaleb
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Neuroscience Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114861/
https://www.ncbi.nlm.nih.gov/pubmed/33995925
http://dx.doi.org/10.32598/bcn.9.10.510
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author Kadkhodaeian, Hamid Aboutaleb
author_facet Kadkhodaeian, Hamid Aboutaleb
author_sort Kadkhodaeian, Hamid Aboutaleb
collection PubMed
description Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcription factors required for retinal progenitor cells are well known, but the generation of these cells from mesenchymal stem cells is an ideal goal. The purpose of the paper is to review novel methods for retinal progenitor cell production and selecting a set of signaling molecules in the presence of adult retinal pigment epithelium and extraocular mesenchyme acting as inducers of retinal cell differentiation.
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spelling pubmed-81148612021-05-14 Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells Kadkhodaeian, Hamid Aboutaleb Basic Clin Neurosci Review Paper Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcription factors required for retinal progenitor cells are well known, but the generation of these cells from mesenchymal stem cells is an ideal goal. The purpose of the paper is to review novel methods for retinal progenitor cell production and selecting a set of signaling molecules in the presence of adult retinal pigment epithelium and extraocular mesenchyme acting as inducers of retinal cell differentiation. Iranian Neuroscience Society 2021 2021-01-01 /pmc/articles/PMC8114861/ /pubmed/33995925 http://dx.doi.org/10.32598/bcn.9.10.510 Text en Copyright© 2021 Iranian Neuroscience Society https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Review Paper
Kadkhodaeian, Hamid Aboutaleb
Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells
title Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells
title_full Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells
title_fullStr Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells
title_full_unstemmed Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells
title_short Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells
title_sort mesenchymal stem cells: signaling pathways in transdifferentiation into retinal progenitor cells
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114861/
https://www.ncbi.nlm.nih.gov/pubmed/33995925
http://dx.doi.org/10.32598/bcn.9.10.510
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