Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development

INTRODUCTION: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics. METHODS: In this study, a gene expression profile from a microarray study was selected for more investigation. RESULTS: The study of Down syndrome...

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Autores principales: Zamanian Azodi, Mona, Rezaei Tavirani, Mostafa, Rezaei Tavirani, Majid, Rostami Nejad, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Neuroscience Society 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114864/
https://www.ncbi.nlm.nih.gov/pubmed/33995930
http://dx.doi.org/10.32598/bcn.12.1.941.6
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author Zamanian Azodi, Mona
Rezaei Tavirani, Mostafa
Rezaei Tavirani, Majid
Rostami Nejad, Mohammad
author_facet Zamanian Azodi, Mona
Rezaei Tavirani, Mostafa
Rezaei Tavirani, Majid
Rostami Nejad, Mohammad
author_sort Zamanian Azodi, Mona
collection PubMed
description INTRODUCTION: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics. METHODS: In this study, a gene expression profile from a microarray study was selected for more investigation. RESULTS: The study of Down syndrome patients shows specific genes with differential expression and network centrality properties. These genes are introduced as RHOA, FGF2, FYN, and CD44, and their level of expression is high in these patients. CONCLUSION: This study suggests that besides chromosomes 21, there are additional contributing chromosomes to the risk of Down syndrome development. Besides, these genes could be used for clinical studies after more analysis.
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spelling pubmed-81148642021-05-14 Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development Zamanian Azodi, Mona Rezaei Tavirani, Mostafa Rezaei Tavirani, Majid Rostami Nejad, Mohammad Basic Clin Neurosci Research Paper INTRODUCTION: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics. METHODS: In this study, a gene expression profile from a microarray study was selected for more investigation. RESULTS: The study of Down syndrome patients shows specific genes with differential expression and network centrality properties. These genes are introduced as RHOA, FGF2, FYN, and CD44, and their level of expression is high in these patients. CONCLUSION: This study suggests that besides chromosomes 21, there are additional contributing chromosomes to the risk of Down syndrome development. Besides, these genes could be used for clinical studies after more analysis. Iranian Neuroscience Society 2021 2021-01-01 /pmc/articles/PMC8114864/ /pubmed/33995930 http://dx.doi.org/10.32598/bcn.12.1.941.6 Text en Copyright© 2021 Iranian Neuroscience Society https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research Paper
Zamanian Azodi, Mona
Rezaei Tavirani, Mostafa
Rezaei Tavirani, Majid
Rostami Nejad, Mohammad
Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development
title Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development
title_full Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development
title_fullStr Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development
title_full_unstemmed Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development
title_short Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development
title_sort bioinformatics investigation and contribution of other chromosomes besides chromosome 21 in the risk of down syndrome development
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114864/
https://www.ncbi.nlm.nih.gov/pubmed/33995930
http://dx.doi.org/10.32598/bcn.12.1.941.6
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