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Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes

Pregnancy-related hormones (PRH) are recognized as important regulators of hepatic cytochrome P450 enzyme expression and function. However, the impact of PRH on the hepatic expression and function of uridine diphosphate glucuronosyltransferases (UGTs) remains unclear. Using primary human hepatocytes...

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Detalles Bibliográficos
Autores principales:	Khatri, Raju, Fallon, John K., Sykes, Craig, Kulick, Natasha, Rementer, Rebecca J. B., Miner, Taryn A., Schauer, Amanda P., Kashuba, Angela D. M., Boggess, Kim A., Brouwer, Kim L. R., Smith, Philip C., Lee, Craig R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115026/ https://www.ncbi.nlm.nih.gov/pubmed/33995076 http://dx.doi.org/10.3389/fphar.2021.655320

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