Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling

In mice, time of day strongly influences lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here we show that feeding, rather than light, controls time-of-day dependent LPS sensitivity. Mortality following LPS administration is independent o...

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Detalles Bibliográficos
Autores principales: Geiger, Sarah S., Traba, Javier, Richoz, Nathan, Farley, Taylor K., Brooks, Stephen R., Petermann, Franziska, Wang, Lingdi, Gonzalez, Frank J., Sack, Michael N., Siegel, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115055/
https://www.ncbi.nlm.nih.gov/pubmed/33980856
http://dx.doi.org/10.1038/s41467-021-22961-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115055/
https://www.ncbi.nlm.nih.gov/pubmed/33980856
http://dx.doi.org/10.1038/s41467-021-22961-z

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