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INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and modeling its interaction with the IN-C-terminal domain (IN-CTD) reveal that INI1-Rpt1/IN-CTD interface residues overlap with those re...
Autores principales: | Dixit, Updesh, Bhutoria, Savita, Wu, Xuhong, Qiu, Liming, Spira, Menachem, Mathew, Sheeba, Harris, Richard, Adams, Lucas J., Cahill, Sean, Pathak, Rajiv, Rajesh Kumar, P., Nguyen, Minh, Acharya, Seetharama A., Brenowitz, Michael, Almo, Steven C., Zou, Xiaoqin, Steven, Alasdair C., Cowburn, David, Girvin, Mark, Kalpana, Ganjam V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115288/ https://www.ncbi.nlm.nih.gov/pubmed/33980829 http://dx.doi.org/10.1038/s41467-021-22733-9 |
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