Paracetamol (acetaminophen) rescues cognitive decline, neuroinflammation and cytoskeletal alterations in a model of post-operative cognitive decline (POCD) in middle-aged rats

Post-operative cognitive dysfunction (POCD) is a debilitating clinical phenomenon in elderly patients. Management of pain in elderly is complicated because analgesic opiates elicit major side effects. In contrast, paracetamol (acetaminophen) has shown analgesic efficacy, no impact on cognition, and...

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Detalles Bibliográficos
Autores principales: Garrone, B., Durando, L., Prenderville, J., Sokolowska, E., Milanese, C., Di Giorgio, F. P., Callaghan, C., Bianchi, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115335/
https://www.ncbi.nlm.nih.gov/pubmed/33980934
http://dx.doi.org/10.1038/s41598-021-89629-y

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