Generation of a chemical genetic model for JAK3

Janus Kinases (JAKs) have emerged as an important drug target for the treatment of a number of immune disorders due to the central role that they play in cytokine signalling. 4 isoforms of JAKs exist in mammalian cells and the ideal isoform profile of a JAK inhibitor has been the subject of much deb...

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Detalles Bibliográficos
Autores principales: Remenyi, Judit, Naik, Rangeetha Jayaprakash, Wang, Jinhua, Razsolkov, Momchil, Verano, Alyssa, Cai, Quan, Tan, Li, Toth, Rachel, Raggett, Samantha, Baillie, Carla, Traynor, Ryan, Hastie, C. James, Gray, Nathanael S., Arthur, J. Simon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115619/
https://www.ncbi.nlm.nih.gov/pubmed/33980892
http://dx.doi.org/10.1038/s41598-021-89356-4

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