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Association of weight fluctuation with cardiovascular disease risk among initially obese adults
The association of fluctuations in body mass index with cardiovascular risk in long-term is not well understood. This study aimed to investigate cardiovascular outcomes of weight fluctuation. Total of 67,101 obese adults from the Korean National Health Insurance Service who received health examinati...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115677/ https://www.ncbi.nlm.nih.gov/pubmed/33980955 http://dx.doi.org/10.1038/s41598-021-89666-7 |
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author | Jeong, Seogsong Choi, Seulggie Chang, Jooyoung Kim, Kyuwoong Kim, Sung Min Hwang, Seo Yun Son, Joung Sik Lee, Gyeongsil Park, Sang Min |
author_facet | Jeong, Seogsong Choi, Seulggie Chang, Jooyoung Kim, Kyuwoong Kim, Sung Min Hwang, Seo Yun Son, Joung Sik Lee, Gyeongsil Park, Sang Min |
author_sort | Jeong, Seogsong |
collection | PubMed |
description | The association of fluctuations in body mass index with cardiovascular risk in long-term is not well understood. This study aimed to investigate cardiovascular outcomes of weight fluctuation. Total of 67,101 obese adults from the Korean National Health Insurance Service who received health examinations in three separate biennial periods were included. Participants were followed up from January 1, 2008 to the date of cardiovascular disease, death, or December 31, 2015, and categorized into 9 distinctive groups according to the BMI. Continuous weight gain showed an increased risk of overall cardiovascular disease (hazard ratio [HR], 2.36; P = 0.007), whereas weight loss after weight maintenance (HR, 0.91; P = 0.016) and weight maintenance after weight loss (HR, 0.91; P = 0.004) were ameliorative compared to the no weight change group. As for coronary heart disease, weight maintenance after weight gain was unfavorable (HR, 1.25; P = 0.004) while weight loss after weight maintenance (HR, 0.82; P < 0.001), weight cycling (HR, 0.83; P = 0.043), and weight maintenance after weight loss (HR, 0.88; P = 0.012) were beneficial. Weight maintenance after weight loss is beneficial for obese adults in terms of cardiovascular risks. In addition, weight loss is in part related to reduced risk of coronary heart disease despite weight cycling. |
format | Online Article Text |
id | pubmed-8115677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81156772021-05-14 Association of weight fluctuation with cardiovascular disease risk among initially obese adults Jeong, Seogsong Choi, Seulggie Chang, Jooyoung Kim, Kyuwoong Kim, Sung Min Hwang, Seo Yun Son, Joung Sik Lee, Gyeongsil Park, Sang Min Sci Rep Article The association of fluctuations in body mass index with cardiovascular risk in long-term is not well understood. This study aimed to investigate cardiovascular outcomes of weight fluctuation. Total of 67,101 obese adults from the Korean National Health Insurance Service who received health examinations in three separate biennial periods were included. Participants were followed up from January 1, 2008 to the date of cardiovascular disease, death, or December 31, 2015, and categorized into 9 distinctive groups according to the BMI. Continuous weight gain showed an increased risk of overall cardiovascular disease (hazard ratio [HR], 2.36; P = 0.007), whereas weight loss after weight maintenance (HR, 0.91; P = 0.016) and weight maintenance after weight loss (HR, 0.91; P = 0.004) were ameliorative compared to the no weight change group. As for coronary heart disease, weight maintenance after weight gain was unfavorable (HR, 1.25; P = 0.004) while weight loss after weight maintenance (HR, 0.82; P < 0.001), weight cycling (HR, 0.83; P = 0.043), and weight maintenance after weight loss (HR, 0.88; P = 0.012) were beneficial. Weight maintenance after weight loss is beneficial for obese adults in terms of cardiovascular risks. In addition, weight loss is in part related to reduced risk of coronary heart disease despite weight cycling. Nature Publishing Group UK 2021-05-12 /pmc/articles/PMC8115677/ /pubmed/33980955 http://dx.doi.org/10.1038/s41598-021-89666-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Jeong, Seogsong Choi, Seulggie Chang, Jooyoung Kim, Kyuwoong Kim, Sung Min Hwang, Seo Yun Son, Joung Sik Lee, Gyeongsil Park, Sang Min Association of weight fluctuation with cardiovascular disease risk among initially obese adults |
title | Association of weight fluctuation with cardiovascular disease risk among initially obese adults |
title_full | Association of weight fluctuation with cardiovascular disease risk among initially obese adults |
title_fullStr | Association of weight fluctuation with cardiovascular disease risk among initially obese adults |
title_full_unstemmed | Association of weight fluctuation with cardiovascular disease risk among initially obese adults |
title_short | Association of weight fluctuation with cardiovascular disease risk among initially obese adults |
title_sort | association of weight fluctuation with cardiovascular disease risk among initially obese adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115677/ https://www.ncbi.nlm.nih.gov/pubmed/33980955 http://dx.doi.org/10.1038/s41598-021-89666-7 |
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