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Leptomeningeal Carcinomatosis in Epithelial Ovarian Cancer: A Diagnostic Challenge

Leptomeningeal carcinomatosis (LCM), also known as neoplastic meningitis, is a rare entity. It is generally seen in solid tumors. Ovarian cancers can infrequently cause LCM. The clinical presentation is variable. Diagnosis is made by a lumbar puncture that shows malignant cells in the cerebrospinal...

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Autores principales: Tahir, Nayha, Ram, Aatma, Jain, Nikita, Vemireddy, Lalitha Padmanabha, Zahra, Farah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115684/
https://www.ncbi.nlm.nih.gov/pubmed/33996304
http://dx.doi.org/10.7759/cureus.14440
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author Tahir, Nayha
Ram, Aatma
Jain, Nikita
Vemireddy, Lalitha Padmanabha
Zahra, Farah
author_facet Tahir, Nayha
Ram, Aatma
Jain, Nikita
Vemireddy, Lalitha Padmanabha
Zahra, Farah
author_sort Tahir, Nayha
collection PubMed
description Leptomeningeal carcinomatosis (LCM), also known as neoplastic meningitis, is a rare entity. It is generally seen in solid tumors. Ovarian cancers can infrequently cause LCM. The clinical presentation is variable. Diagnosis is made by a lumbar puncture that shows malignant cells in the cerebrospinal fluid (CSF) and usually correlates with imaging findings. Given the low individual sensitivities of lumbar puncture (55%) and magnetic resonance imaging (70%), it is recommended to combine both modalities for optimal diagnostic results. Treatment options vary depending on the type of primary carcinoma, however, the prognosis is guarded. We report a case of LCM in a patient with stage IV epithelial ovarian cancer in remission, which became a diagnostic challenge due to a lack of imaging findings.
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spelling pubmed-81156842021-05-14 Leptomeningeal Carcinomatosis in Epithelial Ovarian Cancer: A Diagnostic Challenge Tahir, Nayha Ram, Aatma Jain, Nikita Vemireddy, Lalitha Padmanabha Zahra, Farah Cureus Internal Medicine Leptomeningeal carcinomatosis (LCM), also known as neoplastic meningitis, is a rare entity. It is generally seen in solid tumors. Ovarian cancers can infrequently cause LCM. The clinical presentation is variable. Diagnosis is made by a lumbar puncture that shows malignant cells in the cerebrospinal fluid (CSF) and usually correlates with imaging findings. Given the low individual sensitivities of lumbar puncture (55%) and magnetic resonance imaging (70%), it is recommended to combine both modalities for optimal diagnostic results. Treatment options vary depending on the type of primary carcinoma, however, the prognosis is guarded. We report a case of LCM in a patient with stage IV epithelial ovarian cancer in remission, which became a diagnostic challenge due to a lack of imaging findings. Cureus 2021-04-12 /pmc/articles/PMC8115684/ /pubmed/33996304 http://dx.doi.org/10.7759/cureus.14440 Text en Copyright © 2021, Tahir et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Tahir, Nayha
Ram, Aatma
Jain, Nikita
Vemireddy, Lalitha Padmanabha
Zahra, Farah
Leptomeningeal Carcinomatosis in Epithelial Ovarian Cancer: A Diagnostic Challenge
title Leptomeningeal Carcinomatosis in Epithelial Ovarian Cancer: A Diagnostic Challenge
title_full Leptomeningeal Carcinomatosis in Epithelial Ovarian Cancer: A Diagnostic Challenge
title_fullStr Leptomeningeal Carcinomatosis in Epithelial Ovarian Cancer: A Diagnostic Challenge
title_full_unstemmed Leptomeningeal Carcinomatosis in Epithelial Ovarian Cancer: A Diagnostic Challenge
title_short Leptomeningeal Carcinomatosis in Epithelial Ovarian Cancer: A Diagnostic Challenge
title_sort leptomeningeal carcinomatosis in epithelial ovarian cancer: a diagnostic challenge
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115684/
https://www.ncbi.nlm.nih.gov/pubmed/33996304
http://dx.doi.org/10.7759/cureus.14440
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