Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome

Inflammasomes are filamentous signaling platforms integral to innate immunity. Currently, little is known about how these structurally similar filaments recognize and distinguish one another. A cryo-EM structure of the AIM2(PYD) filament reveals that the architecture of the upstream filament is esse...

Descripción completa

Detalles Bibliográficos
Autores principales: Matyszewski, Mariusz, Zheng, Weili, Lueck, Jacob, Mazanek, Zachary, Mohideen, Naveen, Lau, Albert Y., Egelman, Edward H., Sohn, Jungsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115694/
https://www.ncbi.nlm.nih.gov/pubmed/33980849
http://dx.doi.org/10.1038/s41467-021-23045-8

Ejemplares similares

Ejemplares similares