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Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease

BACKGROUND: Physical inactivity is an important risk factor for cardiovascular disease. The benefits of exercise in patients with chronic diseases, including cardiovascular diseases, are well established. For patients with sickle cell disease, medical recommendation was to avoid physical exercise fo...

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Autores principales: de Araujo Junior, Jonas Alves, Antonelli Rossi, Daniele Andreza, Carneiro Valadão, Taina Fabri, Milan-Mattos, Juliana Cristina, Catai, Aparecida Maria, Sato, Tatiana de Oliveira, Hueb, Joao Carlos, Zanati Bazan, Silmeia Garcia, Hokama, Paula Oliveira Montandon, Hokama, Newton Key, Roscani, Meliza Goi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115779/
https://www.ncbi.nlm.nih.gov/pubmed/33979369
http://dx.doi.org/10.1371/journal.pone.0250128
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author de Araujo Junior, Jonas Alves
Antonelli Rossi, Daniele Andreza
Carneiro Valadão, Taina Fabri
Milan-Mattos, Juliana Cristina
Catai, Aparecida Maria
Sato, Tatiana de Oliveira
Hueb, Joao Carlos
Zanati Bazan, Silmeia Garcia
Hokama, Paula Oliveira Montandon
Hokama, Newton Key
Roscani, Meliza Goi
author_facet de Araujo Junior, Jonas Alves
Antonelli Rossi, Daniele Andreza
Carneiro Valadão, Taina Fabri
Milan-Mattos, Juliana Cristina
Catai, Aparecida Maria
Sato, Tatiana de Oliveira
Hueb, Joao Carlos
Zanati Bazan, Silmeia Garcia
Hokama, Paula Oliveira Montandon
Hokama, Newton Key
Roscani, Meliza Goi
author_sort de Araujo Junior, Jonas Alves
collection PubMed
description BACKGROUND: Physical inactivity is an important risk factor for cardiovascular disease. The benefits of exercise in patients with chronic diseases, including cardiovascular diseases, are well established. For patients with sickle cell disease, medical recommendation was to avoid physical exercise for fear of triggering painful crises or increasing the impairment of the cardiopulmonary function. Only recently, studies have shown safety in exercise programs for this population. Despite that, there is no report that assess the effects of physical exercise on cardiac parameters in patients with sickle cell disease. OBJECTIVE: This study aimed to evaluate the impact of regular physical exercise (a home-based program) on cardiovascular function in patients with sickle cell disease. DESIGN: A quasi-randomized prospective controlled trial. SETTING: During the years 2015 and 2016, we started recruiting among adult patients treated at a Brazilian Center for Patients with Sickle Cell Disease to participate in a study involving a home exercise program. The experimental (exercise) and control groups were submitted to clinical evaluation and cardiovascular tests before and after the intervention. Analysis of variance was applied to compare groups, considering time and group factors. PARTICIPANTS: Twenty-seven adult outpatients with a sickle cell disease diagnosis. INTERVENTIONS: Exercise group (N = 14): a regular home-based aerobic exercise program, three to five times per week not exceeding give times per week, for eight weeks; no prescription for the control group (N = 13). MAIN OUTCOME MEASURES: Echocardiographic and treadmill test parameters. RESULTS: The exercise group showed significant improvement in cardiovascular tests, demonstrated by increased distance traveled on a treadmill (p<0.01), increased ejection fraction (p < 0.01) and improvement of diastolic function assessed by mitral tissue Doppler E’ wave on echocardiography (p = 0.04). None of the patients presented a sickle cell crisis or worsening of symptoms during the exercise program. CONCLUSION: The selected home-based exercise program is safe, feasible, and promotes a favorable impact on functional capacity and cardiovascular function in sickle cell disease patients.
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spelling pubmed-81157792021-05-24 Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease de Araujo Junior, Jonas Alves Antonelli Rossi, Daniele Andreza Carneiro Valadão, Taina Fabri Milan-Mattos, Juliana Cristina Catai, Aparecida Maria Sato, Tatiana de Oliveira Hueb, Joao Carlos Zanati Bazan, Silmeia Garcia Hokama, Paula Oliveira Montandon Hokama, Newton Key Roscani, Meliza Goi PLoS One Research Article BACKGROUND: Physical inactivity is an important risk factor for cardiovascular disease. The benefits of exercise in patients with chronic diseases, including cardiovascular diseases, are well established. For patients with sickle cell disease, medical recommendation was to avoid physical exercise for fear of triggering painful crises or increasing the impairment of the cardiopulmonary function. Only recently, studies have shown safety in exercise programs for this population. Despite that, there is no report that assess the effects of physical exercise on cardiac parameters in patients with sickle cell disease. OBJECTIVE: This study aimed to evaluate the impact of regular physical exercise (a home-based program) on cardiovascular function in patients with sickle cell disease. DESIGN: A quasi-randomized prospective controlled trial. SETTING: During the years 2015 and 2016, we started recruiting among adult patients treated at a Brazilian Center for Patients with Sickle Cell Disease to participate in a study involving a home exercise program. The experimental (exercise) and control groups were submitted to clinical evaluation and cardiovascular tests before and after the intervention. Analysis of variance was applied to compare groups, considering time and group factors. PARTICIPANTS: Twenty-seven adult outpatients with a sickle cell disease diagnosis. INTERVENTIONS: Exercise group (N = 14): a regular home-based aerobic exercise program, three to five times per week not exceeding give times per week, for eight weeks; no prescription for the control group (N = 13). MAIN OUTCOME MEASURES: Echocardiographic and treadmill test parameters. RESULTS: The exercise group showed significant improvement in cardiovascular tests, demonstrated by increased distance traveled on a treadmill (p<0.01), increased ejection fraction (p < 0.01) and improvement of diastolic function assessed by mitral tissue Doppler E’ wave on echocardiography (p = 0.04). None of the patients presented a sickle cell crisis or worsening of symptoms during the exercise program. CONCLUSION: The selected home-based exercise program is safe, feasible, and promotes a favorable impact on functional capacity and cardiovascular function in sickle cell disease patients. Public Library of Science 2021-05-12 /pmc/articles/PMC8115779/ /pubmed/33979369 http://dx.doi.org/10.1371/journal.pone.0250128 Text en © 2021 de Araujo Junior et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
de Araujo Junior, Jonas Alves
Antonelli Rossi, Daniele Andreza
Carneiro Valadão, Taina Fabri
Milan-Mattos, Juliana Cristina
Catai, Aparecida Maria
Sato, Tatiana de Oliveira
Hueb, Joao Carlos
Zanati Bazan, Silmeia Garcia
Hokama, Paula Oliveira Montandon
Hokama, Newton Key
Roscani, Meliza Goi
Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
title Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
title_full Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
title_fullStr Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
title_full_unstemmed Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
title_short Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
title_sort cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115779/
https://www.ncbi.nlm.nih.gov/pubmed/33979369
http://dx.doi.org/10.1371/journal.pone.0250128
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