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Safety, effectiveness and costs of percutaneous mitral valve repair: A real-world prospective study
AIMS: Percutaneous mitral valve leaflet repair is a treatment option for some people with severe mitral valve regurgitation for whom conventional mitral valve surgery is clinically inappropriate. This study aimed to determine the safety, efficacy, and costs of percutaneous mitral valve leaflet repai...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115844/ https://www.ncbi.nlm.nih.gov/pubmed/33979403 http://dx.doi.org/10.1371/journal.pone.0251463 |
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author | Willits, Iain Keltie, Kim de Belder, Mark Henderson, Robert Linker, Nicholas Patrick, Hannah Powell, Helen Berry, Lee Speller, Julie Urwin, Samuel G. Cole, Helen Sims, Andrew J. |
author_facet | Willits, Iain Keltie, Kim de Belder, Mark Henderson, Robert Linker, Nicholas Patrick, Hannah Powell, Helen Berry, Lee Speller, Julie Urwin, Samuel G. Cole, Helen Sims, Andrew J. |
author_sort | Willits, Iain |
collection | PubMed |
description | AIMS: Percutaneous mitral valve leaflet repair is a treatment option for some people with severe mitral valve regurgitation for whom conventional mitral valve surgery is clinically inappropriate. This study aimed to determine the safety, efficacy, and costs of percutaneous mitral valve leaflet repair, using the MitraClip device in a UK setting. METHODS AND RESULTS: This was a prospective, single-armed registry with a follow-up of 2 years that reported a range of procedural, clinical and patient-orientated outcomes. Registry data were linked to routine data sources to allow for more comprehensive follow up concerning mortality and healthcare resource use. The registry received data for 199 mainly elective patients with mixed mitral regurgitation aetiology. A MitraClip device was implanted in 187 patients (94%), with a procedural success rate of 86%, with 8% of patients having a serious in-hospital adverse event (including 5% mortality). Percutaneous mitral valve leaflet repair reduced mitral regurgitation from 100% MR grade ≥ 3+ to 7% at discharge. There were corresponding improvements in New York Heart Association functional class, reducing from 92% (class ≥ 3) at baseline to 18% at 6 weeks. There were significant improvements in generic and disease specific quality of life indicators up to 2 years. The all-cause mortality rate was estimated to be 12.7% (95% CI 7.5 to 17.7%) at 1 year. Percutaneous mitral valve leaflet repair was associated with reduced hospital readmissions and potential cost-savings in post-procedural care. CONCLUSION: This study shows that percutaneous mitral valve leaflet repair using MitraClip is a relatively safe and effective treatment in patients unable to tolerate surgery and has the potential to reduce ongoing healthcare costs in the UK. |
format | Online Article Text |
id | pubmed-8115844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81158442021-05-24 Safety, effectiveness and costs of percutaneous mitral valve repair: A real-world prospective study Willits, Iain Keltie, Kim de Belder, Mark Henderson, Robert Linker, Nicholas Patrick, Hannah Powell, Helen Berry, Lee Speller, Julie Urwin, Samuel G. Cole, Helen Sims, Andrew J. PLoS One Research Article AIMS: Percutaneous mitral valve leaflet repair is a treatment option for some people with severe mitral valve regurgitation for whom conventional mitral valve surgery is clinically inappropriate. This study aimed to determine the safety, efficacy, and costs of percutaneous mitral valve leaflet repair, using the MitraClip device in a UK setting. METHODS AND RESULTS: This was a prospective, single-armed registry with a follow-up of 2 years that reported a range of procedural, clinical and patient-orientated outcomes. Registry data were linked to routine data sources to allow for more comprehensive follow up concerning mortality and healthcare resource use. The registry received data for 199 mainly elective patients with mixed mitral regurgitation aetiology. A MitraClip device was implanted in 187 patients (94%), with a procedural success rate of 86%, with 8% of patients having a serious in-hospital adverse event (including 5% mortality). Percutaneous mitral valve leaflet repair reduced mitral regurgitation from 100% MR grade ≥ 3+ to 7% at discharge. There were corresponding improvements in New York Heart Association functional class, reducing from 92% (class ≥ 3) at baseline to 18% at 6 weeks. There were significant improvements in generic and disease specific quality of life indicators up to 2 years. The all-cause mortality rate was estimated to be 12.7% (95% CI 7.5 to 17.7%) at 1 year. Percutaneous mitral valve leaflet repair was associated with reduced hospital readmissions and potential cost-savings in post-procedural care. CONCLUSION: This study shows that percutaneous mitral valve leaflet repair using MitraClip is a relatively safe and effective treatment in patients unable to tolerate surgery and has the potential to reduce ongoing healthcare costs in the UK. Public Library of Science 2021-05-12 /pmc/articles/PMC8115844/ /pubmed/33979403 http://dx.doi.org/10.1371/journal.pone.0251463 Text en © 2021 Willits et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Willits, Iain Keltie, Kim de Belder, Mark Henderson, Robert Linker, Nicholas Patrick, Hannah Powell, Helen Berry, Lee Speller, Julie Urwin, Samuel G. Cole, Helen Sims, Andrew J. Safety, effectiveness and costs of percutaneous mitral valve repair: A real-world prospective study |
title | Safety, effectiveness and costs of percutaneous mitral valve repair: A real-world prospective study |
title_full | Safety, effectiveness and costs of percutaneous mitral valve repair: A real-world prospective study |
title_fullStr | Safety, effectiveness and costs of percutaneous mitral valve repair: A real-world prospective study |
title_full_unstemmed | Safety, effectiveness and costs of percutaneous mitral valve repair: A real-world prospective study |
title_short | Safety, effectiveness and costs of percutaneous mitral valve repair: A real-world prospective study |
title_sort | safety, effectiveness and costs of percutaneous mitral valve repair: a real-world prospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115844/ https://www.ncbi.nlm.nih.gov/pubmed/33979403 http://dx.doi.org/10.1371/journal.pone.0251463 |
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