Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein

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Understanding how human ACE2 genetic variants differ in their recognition by SARS-CoV-2 can facilitate the leveraging of ACE2 as an axis for treating and preventing COVID-19. In this work, we experimentally interrogate thousands of ACE2 mutants to identify over one hundred human single-nucleotide va...

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Detalles Bibliográficos
Autores principales: Heinzelman, Pete, Romero, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115845/
https://www.ncbi.nlm.nih.gov/pubmed/33979391
http://dx.doi.org/10.1371/journal.pone.0251585

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