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ADEM post-Sars-CoV-2 infection in a pediatric patient with Fisher-Evans syndrome
INTRODUCTION: Sars-CoV-2 is a single-strained RNA virus belonging to Coronaviridae’s family. In pediatric age, the majority of patients is asymptomatic; however, several neurological manifestations associated with Sars-CoV-2 infection have been detected in a percentage of cases ranging from 17.3 to...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115868/ https://www.ncbi.nlm.nih.gov/pubmed/33982145 http://dx.doi.org/10.1007/s10072-021-05311-1 |
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author | Manzo, Maria Laura Galati, Cristina Gallo, Cristina Santangelo, Giuseppe Marino, Antonio Guccione, Fulvio Pitino, Renata Raieli, Vincenzo |
author_facet | Manzo, Maria Laura Galati, Cristina Gallo, Cristina Santangelo, Giuseppe Marino, Antonio Guccione, Fulvio Pitino, Renata Raieli, Vincenzo |
author_sort | Manzo, Maria Laura |
collection | PubMed |
description | INTRODUCTION: Sars-CoV-2 is a single-strained RNA virus belonging to Coronaviridae’s family. In pediatric age, the majority of patients is asymptomatic; however, several neurological manifestations associated with Sars-CoV-2 infection have been detected in a percentage of cases ranging from 17.3 to 36.4%. Acute disseminated encephalomyelitis (ADEM) has been recently included among the potential complications of Sars-Cov2 infection. The available data regarding pediatric patient show only one case. CASE REPORT: We present a case regarding a 6-year-old patient suffering from Fisher-Evans syndrome who was given sirolimus and thalidomide therapy. After 10 days since the first positive nasopharyngeal swab for Sars-CoV-2, in which he had no symptoms, he presented an episode of generalized tonic-clonic seizure with spontaneous resolution. The patient underwent MRI which showed the typical picture of acute disseminated encephalomyelitis. His clinical course was favorable, with a good response to cortisone therapy and a progressive improvement of the neuroradiological and electroencephalographic picture. CONCLUSIONS: According to our knowledge, this is the second case of an acute disseminated encephalomyelitis following SARS-CoV-2 infection in a pediatric patient, characterized by monosymptomatic onset, in which the immunosuppressive therapy practiced for the Fisher-Evans syndrome has probably contributed to a favorable evolution of ADEM, in contrast to other case described in the literature. |
format | Online Article Text |
id | pubmed-8115868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-81158682021-05-13 ADEM post-Sars-CoV-2 infection in a pediatric patient with Fisher-Evans syndrome Manzo, Maria Laura Galati, Cristina Gallo, Cristina Santangelo, Giuseppe Marino, Antonio Guccione, Fulvio Pitino, Renata Raieli, Vincenzo Neurol Sci Brief Communication INTRODUCTION: Sars-CoV-2 is a single-strained RNA virus belonging to Coronaviridae’s family. In pediatric age, the majority of patients is asymptomatic; however, several neurological manifestations associated with Sars-CoV-2 infection have been detected in a percentage of cases ranging from 17.3 to 36.4%. Acute disseminated encephalomyelitis (ADEM) has been recently included among the potential complications of Sars-Cov2 infection. The available data regarding pediatric patient show only one case. CASE REPORT: We present a case regarding a 6-year-old patient suffering from Fisher-Evans syndrome who was given sirolimus and thalidomide therapy. After 10 days since the first positive nasopharyngeal swab for Sars-CoV-2, in which he had no symptoms, he presented an episode of generalized tonic-clonic seizure with spontaneous resolution. The patient underwent MRI which showed the typical picture of acute disseminated encephalomyelitis. His clinical course was favorable, with a good response to cortisone therapy and a progressive improvement of the neuroradiological and electroencephalographic picture. CONCLUSIONS: According to our knowledge, this is the second case of an acute disseminated encephalomyelitis following SARS-CoV-2 infection in a pediatric patient, characterized by monosymptomatic onset, in which the immunosuppressive therapy practiced for the Fisher-Evans syndrome has probably contributed to a favorable evolution of ADEM, in contrast to other case described in the literature. Springer International Publishing 2021-05-12 2021 /pmc/articles/PMC8115868/ /pubmed/33982145 http://dx.doi.org/10.1007/s10072-021-05311-1 Text en © Fondazione Società Italiana di Neurologia 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Brief Communication Manzo, Maria Laura Galati, Cristina Gallo, Cristina Santangelo, Giuseppe Marino, Antonio Guccione, Fulvio Pitino, Renata Raieli, Vincenzo ADEM post-Sars-CoV-2 infection in a pediatric patient with Fisher-Evans syndrome |
title | ADEM post-Sars-CoV-2 infection in a pediatric patient with Fisher-Evans syndrome |
title_full | ADEM post-Sars-CoV-2 infection in a pediatric patient with Fisher-Evans syndrome |
title_fullStr | ADEM post-Sars-CoV-2 infection in a pediatric patient with Fisher-Evans syndrome |
title_full_unstemmed | ADEM post-Sars-CoV-2 infection in a pediatric patient with Fisher-Evans syndrome |
title_short | ADEM post-Sars-CoV-2 infection in a pediatric patient with Fisher-Evans syndrome |
title_sort | adem post-sars-cov-2 infection in a pediatric patient with fisher-evans syndrome |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115868/ https://www.ncbi.nlm.nih.gov/pubmed/33982145 http://dx.doi.org/10.1007/s10072-021-05311-1 |
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