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Functional interferometric diffusing wave spectroscopy of the human brain
Cerebral blood flow (CBF) is essential for brain function, and CBF-related signals can inform us about brain activity. Yet currently, high-end medical instrumentation is needed to perform a CBF measurement in adult humans. Here, we describe functional interferometric diffusing wave spectroscopy (fiD...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115931/ https://www.ncbi.nlm.nih.gov/pubmed/33980479 http://dx.doi.org/10.1126/sciadv.abe0150 |
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author | Zhou, Wenjun Kholiqov, Oybek Zhu, Jun Zhao, Mingjun Zimmermann, Lara L. Martin, Ryan M. Lyeth, Bruce G. Srinivasan, Vivek J. |
author_facet | Zhou, Wenjun Kholiqov, Oybek Zhu, Jun Zhao, Mingjun Zimmermann, Lara L. Martin, Ryan M. Lyeth, Bruce G. Srinivasan, Vivek J. |
author_sort | Zhou, Wenjun |
collection | PubMed |
description | Cerebral blood flow (CBF) is essential for brain function, and CBF-related signals can inform us about brain activity. Yet currently, high-end medical instrumentation is needed to perform a CBF measurement in adult humans. Here, we describe functional interferometric diffusing wave spectroscopy (fiDWS), which introduces and collects near-infrared light via the scalp, using inexpensive detector arrays to rapidly monitor coherent light fluctuations that encode brain blood flow index (BFI), a surrogate for CBF. Compared to other functional optical approaches, fiDWS measures BFI faster and deeper while also providing continuous wave absorption signals. Achieving clear pulsatile BFI waveforms at source-collector separations of 3.5 cm, we confirm that optical BFI, not absorption, shows a graded hypercapnic response consistent with human cerebrovascular physiology, and that BFI has a better contrast-to-noise ratio than absorption during brain activation. By providing high-throughput measurements of optical BFI at low cost, fiDWS will expand access to CBF. |
format | Online Article Text |
id | pubmed-8115931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81159312021-05-19 Functional interferometric diffusing wave spectroscopy of the human brain Zhou, Wenjun Kholiqov, Oybek Zhu, Jun Zhao, Mingjun Zimmermann, Lara L. Martin, Ryan M. Lyeth, Bruce G. Srinivasan, Vivek J. Sci Adv Research Articles Cerebral blood flow (CBF) is essential for brain function, and CBF-related signals can inform us about brain activity. Yet currently, high-end medical instrumentation is needed to perform a CBF measurement in adult humans. Here, we describe functional interferometric diffusing wave spectroscopy (fiDWS), which introduces and collects near-infrared light via the scalp, using inexpensive detector arrays to rapidly monitor coherent light fluctuations that encode brain blood flow index (BFI), a surrogate for CBF. Compared to other functional optical approaches, fiDWS measures BFI faster and deeper while also providing continuous wave absorption signals. Achieving clear pulsatile BFI waveforms at source-collector separations of 3.5 cm, we confirm that optical BFI, not absorption, shows a graded hypercapnic response consistent with human cerebrovascular physiology, and that BFI has a better contrast-to-noise ratio than absorption during brain activation. By providing high-throughput measurements of optical BFI at low cost, fiDWS will expand access to CBF. American Association for the Advancement of Science 2021-05-12 /pmc/articles/PMC8115931/ /pubmed/33980479 http://dx.doi.org/10.1126/sciadv.abe0150 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Zhou, Wenjun Kholiqov, Oybek Zhu, Jun Zhao, Mingjun Zimmermann, Lara L. Martin, Ryan M. Lyeth, Bruce G. Srinivasan, Vivek J. Functional interferometric diffusing wave spectroscopy of the human brain |
title | Functional interferometric diffusing wave spectroscopy of the human brain |
title_full | Functional interferometric diffusing wave spectroscopy of the human brain |
title_fullStr | Functional interferometric diffusing wave spectroscopy of the human brain |
title_full_unstemmed | Functional interferometric diffusing wave spectroscopy of the human brain |
title_short | Functional interferometric diffusing wave spectroscopy of the human brain |
title_sort | functional interferometric diffusing wave spectroscopy of the human brain |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115931/ https://www.ncbi.nlm.nih.gov/pubmed/33980479 http://dx.doi.org/10.1126/sciadv.abe0150 |
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