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Pneumothorax in critically ill patients with COVID-19 infection: Incidence, clinical characteristics and outcomes in a case control multicenter study

BACKGROUND: The clinical features and outcomes of mechanically ventilated patients with COVID-19 infection who develop a pneumothorax has not been rigorously described or compared to those who do not develop a pneumothorax. PURPOSE: To determine the incidence, clinical characteristics, and outcomes...

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Autores principales: Chopra, Amit, Al-Tarbsheh, Ali Hani, Shah, Nidhi J., Yaqoob, Hamid, Hu, Kurt, Feustel, Paul J., Ortiz-Pacheco, Ronaldo, Patel, Kinner M., Oweis, Jozef, Kozlova, Natalya, Zouridis, Spyridon, Ahmad, Sahar, Epelbaum, Oleg, Chong, Woon H., Huggins, John T., Saha, Biplab K., Conuel, Edward, Chieng, Hau, Mullins, Jeannette, Bajaj, Divyansh, Shkolnik, Boris, Vancavage, Rachel, Madisi, Nagendra, Judson, Marc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116127/
https://www.ncbi.nlm.nih.gov/pubmed/34044224
http://dx.doi.org/10.1016/j.rmed.2021.106464
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author Chopra, Amit
Al-Tarbsheh, Ali Hani
Shah, Nidhi J.
Yaqoob, Hamid
Hu, Kurt
Feustel, Paul J.
Ortiz-Pacheco, Ronaldo
Patel, Kinner M.
Oweis, Jozef
Kozlova, Natalya
Zouridis, Spyridon
Ahmad, Sahar
Epelbaum, Oleg
Chong, Woon H.
Huggins, John T.
Saha, Biplab K.
Conuel, Edward
Chieng, Hau
Mullins, Jeannette
Bajaj, Divyansh
Shkolnik, Boris
Vancavage, Rachel
Madisi, Nagendra
Judson, Marc A.
author_facet Chopra, Amit
Al-Tarbsheh, Ali Hani
Shah, Nidhi J.
Yaqoob, Hamid
Hu, Kurt
Feustel, Paul J.
Ortiz-Pacheco, Ronaldo
Patel, Kinner M.
Oweis, Jozef
Kozlova, Natalya
Zouridis, Spyridon
Ahmad, Sahar
Epelbaum, Oleg
Chong, Woon H.
Huggins, John T.
Saha, Biplab K.
Conuel, Edward
Chieng, Hau
Mullins, Jeannette
Bajaj, Divyansh
Shkolnik, Boris
Vancavage, Rachel
Madisi, Nagendra
Judson, Marc A.
author_sort Chopra, Amit
collection PubMed
description BACKGROUND: The clinical features and outcomes of mechanically ventilated patients with COVID-19 infection who develop a pneumothorax has not been rigorously described or compared to those who do not develop a pneumothorax. PURPOSE: To determine the incidence, clinical characteristics, and outcomes of critically ill patients with COVID-19 infection who developed pneumothorax. In addition, we compared the clinical characteristics and outcomes of mechanically ventilated patients who developed a pneumothorax with those who did not develop a pneumothorax. METHODS: This study was a multicenter retrospective analysis of all adult critically ill patients with COVID-19 infection who were admitted to intensive care units in 4 tertiary care centers in the United States. RESULTS: A total of 842 critically ill patients with COVID-19 infection were analyzed, out of which 594 (71%) were mechanically ventilated. The overall incidence of pneumothorax was 85/842 (10%), and 80/594 (13%) in those who were mechanically ventilated. As compared to mechanically ventilated patients in the non-pneumothorax group, mechanically ventilated patients in the pneumothorax group had worse respiratory parameters at the time of intubation (mean PaO(2):FiO(2) ratio 105 vs 150, P<0.001 and static respiratory system compliance: 30ml/cmH(2)O vs 39ml/cmH(2)O, P = 0.01) and significantly higher in-hospital mortality (63% vs 49%, P = 0.04). CONCLUSION: The overall incidence of pneumothorax in mechanically ventilated patients with COVID-19 infection was 13%. Mechanically ventilated patients with COVID-19 infection who developed pneumothorax had worse gas exchange and respiratory mechanics at the time of intubation and had a higher mortality compared to those who did not develop pneumothorax.
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spelling pubmed-81161272021-05-13 Pneumothorax in critically ill patients with COVID-19 infection: Incidence, clinical characteristics and outcomes in a case control multicenter study Chopra, Amit Al-Tarbsheh, Ali Hani Shah, Nidhi J. Yaqoob, Hamid Hu, Kurt Feustel, Paul J. Ortiz-Pacheco, Ronaldo Patel, Kinner M. Oweis, Jozef Kozlova, Natalya Zouridis, Spyridon Ahmad, Sahar Epelbaum, Oleg Chong, Woon H. Huggins, John T. Saha, Biplab K. Conuel, Edward Chieng, Hau Mullins, Jeannette Bajaj, Divyansh Shkolnik, Boris Vancavage, Rachel Madisi, Nagendra Judson, Marc A. Respir Med Original Research BACKGROUND: The clinical features and outcomes of mechanically ventilated patients with COVID-19 infection who develop a pneumothorax has not been rigorously described or compared to those who do not develop a pneumothorax. PURPOSE: To determine the incidence, clinical characteristics, and outcomes of critically ill patients with COVID-19 infection who developed pneumothorax. In addition, we compared the clinical characteristics and outcomes of mechanically ventilated patients who developed a pneumothorax with those who did not develop a pneumothorax. METHODS: This study was a multicenter retrospective analysis of all adult critically ill patients with COVID-19 infection who were admitted to intensive care units in 4 tertiary care centers in the United States. RESULTS: A total of 842 critically ill patients with COVID-19 infection were analyzed, out of which 594 (71%) were mechanically ventilated. The overall incidence of pneumothorax was 85/842 (10%), and 80/594 (13%) in those who were mechanically ventilated. As compared to mechanically ventilated patients in the non-pneumothorax group, mechanically ventilated patients in the pneumothorax group had worse respiratory parameters at the time of intubation (mean PaO(2):FiO(2) ratio 105 vs 150, P<0.001 and static respiratory system compliance: 30ml/cmH(2)O vs 39ml/cmH(2)O, P = 0.01) and significantly higher in-hospital mortality (63% vs 49%, P = 0.04). CONCLUSION: The overall incidence of pneumothorax in mechanically ventilated patients with COVID-19 infection was 13%. Mechanically ventilated patients with COVID-19 infection who developed pneumothorax had worse gas exchange and respiratory mechanics at the time of intubation and had a higher mortality compared to those who did not develop pneumothorax. Elsevier Ltd. 2021-08 2021-05-13 /pmc/articles/PMC8116127/ /pubmed/34044224 http://dx.doi.org/10.1016/j.rmed.2021.106464 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Research
Chopra, Amit
Al-Tarbsheh, Ali Hani
Shah, Nidhi J.
Yaqoob, Hamid
Hu, Kurt
Feustel, Paul J.
Ortiz-Pacheco, Ronaldo
Patel, Kinner M.
Oweis, Jozef
Kozlova, Natalya
Zouridis, Spyridon
Ahmad, Sahar
Epelbaum, Oleg
Chong, Woon H.
Huggins, John T.
Saha, Biplab K.
Conuel, Edward
Chieng, Hau
Mullins, Jeannette
Bajaj, Divyansh
Shkolnik, Boris
Vancavage, Rachel
Madisi, Nagendra
Judson, Marc A.
Pneumothorax in critically ill patients with COVID-19 infection: Incidence, clinical characteristics and outcomes in a case control multicenter study
title Pneumothorax in critically ill patients with COVID-19 infection: Incidence, clinical characteristics and outcomes in a case control multicenter study
title_full Pneumothorax in critically ill patients with COVID-19 infection: Incidence, clinical characteristics and outcomes in a case control multicenter study
title_fullStr Pneumothorax in critically ill patients with COVID-19 infection: Incidence, clinical characteristics and outcomes in a case control multicenter study
title_full_unstemmed Pneumothorax in critically ill patients with COVID-19 infection: Incidence, clinical characteristics and outcomes in a case control multicenter study
title_short Pneumothorax in critically ill patients with COVID-19 infection: Incidence, clinical characteristics and outcomes in a case control multicenter study
title_sort pneumothorax in critically ill patients with covid-19 infection: incidence, clinical characteristics and outcomes in a case control multicenter study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116127/
https://www.ncbi.nlm.nih.gov/pubmed/34044224
http://dx.doi.org/10.1016/j.rmed.2021.106464
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