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Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world; however, it lacks effective and safe treatments. Ginkgo biloba dropping pill (GBDP), a unique Chinese G. biloba leaf extract preparation, exhibits antioxidant and neuroprotective effects and has a potential as...

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Autores principales: Yu, Dingyi, Zhang, Pengli, Li, Junying, Liu, Ting, Zhang, Yaodan, Wang, Qingqing, Zhang, Jianbing, Lu, Xiaoyan, Fan, Xiaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116202/
https://www.ncbi.nlm.nih.gov/pubmed/34012698
http://dx.doi.org/10.1016/j.jpha.2020.06.002
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author Yu, Dingyi
Zhang, Pengli
Li, Junying
Liu, Ting
Zhang, Yaodan
Wang, Qingqing
Zhang, Jianbing
Lu, Xiaoyan
Fan, Xiaohui
author_facet Yu, Dingyi
Zhang, Pengli
Li, Junying
Liu, Ting
Zhang, Yaodan
Wang, Qingqing
Zhang, Jianbing
Lu, Xiaoyan
Fan, Xiaohui
author_sort Yu, Dingyi
collection PubMed
description Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world; however, it lacks effective and safe treatments. Ginkgo biloba dropping pill (GBDP), a unique Chinese G. biloba leaf extract preparation, exhibits antioxidant and neuroprotective effects and has a potential as an alternative therapy for PD. Thus, the aims of this study were to evaluate the effects of GBDP in in vitro and in vivo PD models and to compare the chemical constituents and pharmacological activities of GBDP and the G. biloba extract EGb 761. Using liquid chromatography tandem-mass spectrometry, 46 GBDP constituents were identified. Principal component analysis identified differences in the chemical profiles of GBDP and EGb 761. A quantitative analysis of 12 constituents showed that GBDP had higher levels of several flavonoids and terpene trilactones than EGb 761, whereas EGb 761 had higher levels of organic acids. Moreover, we found that GBDP prevented 6-hydroxydopamine-induced dopaminergic neuron loss in zebrafish and improved cognitive impairment and neuronal damage in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mice. Although similar effects were observed after EGb 761 treatment, the neuroprotective effects were greater after GBDP treatment on several endpoints. In addition, in vitro results suggested that the Akt/GSK3β pathway may be involved in the neuroprotective effects of GBDP. These findings demonstrated that GBDP have potential neuroprotective effects in the treatment of PD.
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spelling pubmed-81162022021-05-18 Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease Yu, Dingyi Zhang, Pengli Li, Junying Liu, Ting Zhang, Yaodan Wang, Qingqing Zhang, Jianbing Lu, Xiaoyan Fan, Xiaohui J Pharm Anal Original Article Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world; however, it lacks effective and safe treatments. Ginkgo biloba dropping pill (GBDP), a unique Chinese G. biloba leaf extract preparation, exhibits antioxidant and neuroprotective effects and has a potential as an alternative therapy for PD. Thus, the aims of this study were to evaluate the effects of GBDP in in vitro and in vivo PD models and to compare the chemical constituents and pharmacological activities of GBDP and the G. biloba extract EGb 761. Using liquid chromatography tandem-mass spectrometry, 46 GBDP constituents were identified. Principal component analysis identified differences in the chemical profiles of GBDP and EGb 761. A quantitative analysis of 12 constituents showed that GBDP had higher levels of several flavonoids and terpene trilactones than EGb 761, whereas EGb 761 had higher levels of organic acids. Moreover, we found that GBDP prevented 6-hydroxydopamine-induced dopaminergic neuron loss in zebrafish and improved cognitive impairment and neuronal damage in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mice. Although similar effects were observed after EGb 761 treatment, the neuroprotective effects were greater after GBDP treatment on several endpoints. In addition, in vitro results suggested that the Akt/GSK3β pathway may be involved in the neuroprotective effects of GBDP. These findings demonstrated that GBDP have potential neuroprotective effects in the treatment of PD. Xi'an Jiaotong University 2021-04 2020-06-20 /pmc/articles/PMC8116202/ /pubmed/34012698 http://dx.doi.org/10.1016/j.jpha.2020.06.002 Text en © 2020 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Yu, Dingyi
Zhang, Pengli
Li, Junying
Liu, Ting
Zhang, Yaodan
Wang, Qingqing
Zhang, Jianbing
Lu, Xiaoyan
Fan, Xiaohui
Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease
title Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease
title_full Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease
title_fullStr Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease
title_full_unstemmed Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease
title_short Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease
title_sort neuroprotective effects of ginkgo biloba dropping pills in parkinson’s disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116202/
https://www.ncbi.nlm.nih.gov/pubmed/34012698
http://dx.doi.org/10.1016/j.jpha.2020.06.002
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