Cargando…

CSF3R T618I, SETBP1 G870S, SRSF2 P95H, and ASXL1 Q780* tetramutation co-contribute to myeloblast transformation in a chronic neutrophilic leukemia

Chronic neutrophilic leukemia (CNL) is a rare but serious myeloid malignancy. In a review of reported cases for WHO-defined CNL, CSF3R mutation is found in about 90% cases and confirmed as the molecular basis of CNL. Concurrent mutations are observed in CSF3R-mutated CNL patients, including ASXL1, S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qian, Yi, Chen, Yan, Li, Xiaoming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116236/ https://www.ncbi.nlm.nih.gov/pubmed/33822276 http://dx.doi.org/10.1007/s00277-021-04491-2

Ejemplares similares

Impact of TET2, SRSF2, ASXL1 and SETBP1 mutations on survival of patients with chronic myelomonocytic leukemia
por: Cui, Yajuan, et al.
Publicado: (2015)

Clinical significance of CSF3R, SRSF2 and SETBP1 mutations in chronic neutrophilic leukemia and chronic myelomonocytic leukemia
por: Ouyang, Yuan, et al.
Publicado: (2017)

Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS
por: Kanagal-Shamanna, Rashmi, et al.
Publicado: (2016)

SETBP1 Mutations Drive Leukemic Transformation in ASXL1-Mutated MDS
por: Inoue, Daichi, et al.
Publicado: (2014)

CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia
por: Cui, Yajuan, et al.
Publicado: (2014)

ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation
por: Saika, Makoto, et al.
Publicado: (2018)

CSF3R T618I mutant chronic myelomonocytic leukemia (CMML) defines a proliferative CMML subtype enriched in ASXL1 mutations with adverse outcomes
por: Bezerra, Evandro D., et al.
Publicado: (2021)

Identification of a novel de novo mutation of SETBP1 and new findings of SETBP1 in tumorgenesis
por: Wang, Hongdan, et al.
Publicado: (2023)

Alteration of the SETBP1 Gene and Splicing Pathway Genes SF3B1, U2AF1, and SRSF2 in Childhood Acute Myeloid Leukemia
por: Choi, Hyun-Woo, et al.
Publicado: (2015)

Somatic SETBP1 mutations in myeloid malignancies
por: Makishima, Hideki, et al.
Publicado: (2013)

Rare evolution of CSF3R-mutated chronic neutrophilic leukemia to t(4;12)(q12;p13) acute myeloid leukemia with SETBP1 mutation
por: Hirao, Maki, et al.
Publicado: (2022)

Myeloid Disease with the CSF3R T618I Mutation after CLL
por: Couto, Maria Eduarda, et al.
Publicado: (2020)

Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish
por: Fang, Xiao, et al.
Publicado: (2021)

SETBP1 dysregulation in congenital disorders and myeloid neoplasms
por: Coccaro, Nicoletta, et al.
Publicado: (2017)

The Role of SETBP1 in Gastric Cancer: Friend or Foe
por: Fang, Fujin, et al.
Publicado: (2022)

P780: G-CSF THERAPY IN EUROPEAN PATIENTS WITH SHWACHMAN-DIAMOND SYNDROME
por: Mellor-Heineke, Sabine, et al.
Publicado: (2023)

Rapid progression of myelofibrosis in polycythemia vera patient carrying SRSF2 c.284C>A p.(Pro95His) and unique ASXL1 splice site c.1720‐2A>G variant
por: Kanduła, Zuzanna, et al.
Publicado: (2022)

Anti-inflammatory effects of ruxolitinib on chronic neutrophilic leukemia harboring CSF3R-T618I mutation with bilateral renal abscesses
por: Sahara, Naohi, et al.
Publicado: (2022)

Successful Allogeneic Stem Cell Transplantation with Ruxolitinib Maintenance Therapy for CSF3R T618I Mutant Chronic Neutrophilic Leukemia
por: Ye, Peipei, et al.
Publicado: (2023)

The recurrent SETBP1 c.2608G > A, p.(Gly870Ser) variant in a patient with Schinzel-Giedion syndrome: an illustrative case of the utility of whole exome sequencing in a critically ill neonate
por: Leone, Maria Pia, et al.
Publicado: (2020)

Comparison of MiniMed 780G system performance in users aged younger and older than 15 years: Evidence from 12 870 real‐world users
por: Arrieta, Arcelia, et al.
Publicado: (2022)

CSF3R T618I Collaborates With RUNX1-RUNX1T1 to Expand Hematopoietic Progenitors and Sensitizes to GLI Inhibition
por: Swoboda, Anja S., et al.
Publicado: (2023)

Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells
por: Gautrey, Hannah L., et al.
Publicado: (2012)

Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation
por: Nguyen, Nhu, et al.
Publicado: (2021)

Acute Myeloid Leukemia with Co-mutated ASXL1 and SRSF2 Exhibits Monocytic Differentiation and has a Mutational Profile Overlapping with Chronic Myelomonocytic Leukemia
por: Johnson, Steven M., et al.
Publicado: (2019)

Novel SETBP1 mutation in a chinese family with intellectual disability
por: Wang, Le, et al.
Publicado: (2023)

Prognostic significance of SETBP1 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia, and chronic neutrophilic leukemia: A meta-analysis
por: Shou, Li-Hong, et al.
Publicado: (2017)

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1–BAP1 complex
por: Balasubramani, Anand, et al.
Publicado: (2015)

Eighty-year-old man with rare chronic neutrophilic leukemia caused by CSF3R T618I mutation: A case report and review of literature
por: Li, Ya-Ping, et al.
Publicado: (2020)

SETBP1 mutations as a biomarker for myelodysplasia /myeloproliferative neoplasm overlap syndrome
por: Linder, Katherine, et al.
Publicado: (2017)

Myb expression is critical for myeloid leukemia development induced by Setbp1 activation
por: Nguyen, Nhu, et al.
Publicado: (2016)

Putative Roles of SETBP1 Dosage on the SET Oncogene to Affect Brain Development
por: Antonyan, Lilit, et al.
Publicado: (2022)

SETBP1 mutation determines sensitivity to immune checkpoint inhibitors in melanoma and NSCLC
por: An, Fengxiao, et al.
Publicado: (2023)

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network
por: Xia, Yu-Kun, et al.
Publicado: (2020)

CSF3R T618I co-occurs with mutations of splicing and epigenetic genes and with a new PIM3 truncated fusion gene in chronic neutrophilic leukemia
por: Menezes, J, et al.
Publicado: (2013)

ASXL1 plays an important role in erythropoiesis
por: Shi, Hui, et al.
Publicado: (2016)

ASXL1/2 mutations and myeloid malignancies
por: Medina, Edward A., et al.
Publicado: (2022)

Granulocyte function in myeloblastic leukaemia.
por: Wilkinson, P. M., et al.
Publicado: (1975)

Examining the neurodevelopmental and motor phenotypes of Bohring-Opitz syndrome (ASXL1) and Bainbridge-Ropers syndrome (ASXL3)
por: Ayoub, Maya C., et al.
Publicado: (2023)

STUDIES ON THE MATURATION OF MYELOBLASTS INTO MYELOCYTES AND ON AMITOTIC CELL DIVISION IN THE PERIPHERAL BLOOD IN SUBACUTE MYELOBLASTIC LEUCEMIA
por: Sabin, F. R., et al.
Publicado: (1924)

Cannot write session to /tmp/vufind_sessions/sess_c12v3ah3etvnbkp05v3uhh92e3