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Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry
Abdominal paragangliomas and pheochromocytomas (PPGLs) are rare neuroendocrine tumors of the infradiaphragmatic paraganglia and adrenal medulla, respectively. Although few pathologists outside of endocrine tertiary centers will ever diagnose such a lesion, the tumors are well known through the medic...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer US
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116282/ https://www.ncbi.nlm.nih.gov/pubmed/33768452 http://dx.doi.org/10.1007/s12022-021-09675-0 |
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author | Juhlin, C. Christofer |
author_facet | Juhlin, C. Christofer |
author_sort | Juhlin, C. Christofer |
collection | PubMed |
description | Abdominal paragangliomas and pheochromocytomas (PPGLs) are rare neuroendocrine tumors of the infradiaphragmatic paraganglia and adrenal medulla, respectively. Although few pathologists outside of endocrine tertiary centers will ever diagnose such a lesion, the tumors are well known through the medical community—possible due to a combination of the sheer rarity, their often-spectacular presentation due to excess catecholamine secretion as well as their unrivaled coupling to constitutional susceptibility gene mutations and hereditary syndromes. All PPGLs are thought to harbor malignant potential, and therefore pose several challenges to the practicing pathologist. Specifically, a responsible diagnostician should recognize both the capacity and limitations of histological, immunohistochemical, and molecular algorithms to pinpoint high risk for future metastatic disease. This focused review aims to provide the surgical pathologist with a condensed update regarding the current strategies available in order to deliver an accurate prognostication of these enigmatic lesions. |
format | Online Article Text |
id | pubmed-8116282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-81162822021-05-26 Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry Juhlin, C. Christofer Endocr Pathol Article Abdominal paragangliomas and pheochromocytomas (PPGLs) are rare neuroendocrine tumors of the infradiaphragmatic paraganglia and adrenal medulla, respectively. Although few pathologists outside of endocrine tertiary centers will ever diagnose such a lesion, the tumors are well known through the medical community—possible due to a combination of the sheer rarity, their often-spectacular presentation due to excess catecholamine secretion as well as their unrivaled coupling to constitutional susceptibility gene mutations and hereditary syndromes. All PPGLs are thought to harbor malignant potential, and therefore pose several challenges to the practicing pathologist. Specifically, a responsible diagnostician should recognize both the capacity and limitations of histological, immunohistochemical, and molecular algorithms to pinpoint high risk for future metastatic disease. This focused review aims to provide the surgical pathologist with a condensed update regarding the current strategies available in order to deliver an accurate prognostication of these enigmatic lesions. Springer US 2021-03-25 2021 /pmc/articles/PMC8116282/ /pubmed/33768452 http://dx.doi.org/10.1007/s12022-021-09675-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Juhlin, C. Christofer Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry |
title | Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry |
title_full | Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry |
title_fullStr | Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry |
title_full_unstemmed | Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry |
title_short | Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry |
title_sort | challenges in paragangliomas and pheochromocytomas: from histology to molecular immunohistochemistry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116282/ https://www.ncbi.nlm.nih.gov/pubmed/33768452 http://dx.doi.org/10.1007/s12022-021-09675-0 |
work_keys_str_mv | AT juhlincchristofer challengesinparagangliomasandpheochromocytomasfromhistologytomolecularimmunohistochemistry |