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Abnormality of Resting-State Functional Connectivity in Major Depressive Disorder: A Study With Whole-Head Near-Infrared Spectroscopy

Near-infrared spectroscopy (NIRS) is a functional neuroimaging modality that has advantages in clinical usage. Previous functional magnetic resonance imaging (fMRI) studies have found that the resting-state functional connectivity (RSFC) of the default mode network (DMN) is increased, while the RSFC...

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Autores principales: Sakakibara, Eisuke, Satomura, Yoshihiro, Matsuoka, Jun, Koike, Shinsuke, Okada, Naohiro, Sakurada, Hanako, Yamagishi, Mika, Kawakami, Norito, Kasai, Kiyoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116563/
https://www.ncbi.nlm.nih.gov/pubmed/33995150
http://dx.doi.org/10.3389/fpsyt.2021.664859
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author Sakakibara, Eisuke
Satomura, Yoshihiro
Matsuoka, Jun
Koike, Shinsuke
Okada, Naohiro
Sakurada, Hanako
Yamagishi, Mika
Kawakami, Norito
Kasai, Kiyoto
author_facet Sakakibara, Eisuke
Satomura, Yoshihiro
Matsuoka, Jun
Koike, Shinsuke
Okada, Naohiro
Sakurada, Hanako
Yamagishi, Mika
Kawakami, Norito
Kasai, Kiyoto
author_sort Sakakibara, Eisuke
collection PubMed
description Near-infrared spectroscopy (NIRS) is a functional neuroimaging modality that has advantages in clinical usage. Previous functional magnetic resonance imaging (fMRI) studies have found that the resting-state functional connectivity (RSFC) of the default mode network (DMN) is increased, while the RSFC of the cognitive control network (CCN) is reduced in patients with major depressive disorder (MDD) compared with healthy controls. This study tested whether the NIRS-based RSFC measurements can detect the abnormalities in RSFC that have been associated with MDD in previous fMRI studies. We measured 8 min of resting-state brain activity in 34 individuals with MDD and 78 age- and gender-matched healthy controls using a whole-head NIRS system. We applied a previously established partial correlation analysis for estimating RSFCs between the 17 cortical regions. We found that MDD patients had a lower RSFC between the left dorsolateral prefrontal cortex and the parietal lobe that comprise the CCN, and a higher RSFC between the right orbitofrontal cortex and ventrolateral prefrontal cortex, compared to those in healthy controls. The RSFC strength of the left CCN was negatively correlated with the severity of depressive symptoms and the dose of antipsychotic medication and positively correlated with the level of social functioning. The results of this study suggest that NIRS-based measurements of RSFCs have potential clinical applications.
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spelling pubmed-81165632021-05-14 Abnormality of Resting-State Functional Connectivity in Major Depressive Disorder: A Study With Whole-Head Near-Infrared Spectroscopy Sakakibara, Eisuke Satomura, Yoshihiro Matsuoka, Jun Koike, Shinsuke Okada, Naohiro Sakurada, Hanako Yamagishi, Mika Kawakami, Norito Kasai, Kiyoto Front Psychiatry Psychiatry Near-infrared spectroscopy (NIRS) is a functional neuroimaging modality that has advantages in clinical usage. Previous functional magnetic resonance imaging (fMRI) studies have found that the resting-state functional connectivity (RSFC) of the default mode network (DMN) is increased, while the RSFC of the cognitive control network (CCN) is reduced in patients with major depressive disorder (MDD) compared with healthy controls. This study tested whether the NIRS-based RSFC measurements can detect the abnormalities in RSFC that have been associated with MDD in previous fMRI studies. We measured 8 min of resting-state brain activity in 34 individuals with MDD and 78 age- and gender-matched healthy controls using a whole-head NIRS system. We applied a previously established partial correlation analysis for estimating RSFCs between the 17 cortical regions. We found that MDD patients had a lower RSFC between the left dorsolateral prefrontal cortex and the parietal lobe that comprise the CCN, and a higher RSFC between the right orbitofrontal cortex and ventrolateral prefrontal cortex, compared to those in healthy controls. The RSFC strength of the left CCN was negatively correlated with the severity of depressive symptoms and the dose of antipsychotic medication and positively correlated with the level of social functioning. The results of this study suggest that NIRS-based measurements of RSFCs have potential clinical applications. Frontiers Media S.A. 2021-04-29 /pmc/articles/PMC8116563/ /pubmed/33995150 http://dx.doi.org/10.3389/fpsyt.2021.664859 Text en Copyright © 2021 Sakakibara, Satomura, Matsuoka, Koike, Okada, Sakurada, Yamagishi, Kawakami and Kasai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Sakakibara, Eisuke
Satomura, Yoshihiro
Matsuoka, Jun
Koike, Shinsuke
Okada, Naohiro
Sakurada, Hanako
Yamagishi, Mika
Kawakami, Norito
Kasai, Kiyoto
Abnormality of Resting-State Functional Connectivity in Major Depressive Disorder: A Study With Whole-Head Near-Infrared Spectroscopy
title Abnormality of Resting-State Functional Connectivity in Major Depressive Disorder: A Study With Whole-Head Near-Infrared Spectroscopy
title_full Abnormality of Resting-State Functional Connectivity in Major Depressive Disorder: A Study With Whole-Head Near-Infrared Spectroscopy
title_fullStr Abnormality of Resting-State Functional Connectivity in Major Depressive Disorder: A Study With Whole-Head Near-Infrared Spectroscopy
title_full_unstemmed Abnormality of Resting-State Functional Connectivity in Major Depressive Disorder: A Study With Whole-Head Near-Infrared Spectroscopy
title_short Abnormality of Resting-State Functional Connectivity in Major Depressive Disorder: A Study With Whole-Head Near-Infrared Spectroscopy
title_sort abnormality of resting-state functional connectivity in major depressive disorder: a study with whole-head near-infrared spectroscopy
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116563/
https://www.ncbi.nlm.nih.gov/pubmed/33995150
http://dx.doi.org/10.3389/fpsyt.2021.664859
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