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Current Status and Limitations of Myocardial Infarction Large Animal Models in Cardiovascular Translational Research
Establishing an appropriate disease model that mimics the complexities of human cardiovascular disease is critical for evaluating the clinical efficacy and translation success. The multifaceted and complex nature of human ischemic heart disease is difficult to recapitulate in animal models. This dif...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116580/ https://www.ncbi.nlm.nih.gov/pubmed/33996785 http://dx.doi.org/10.3389/fbioe.2021.673683 |
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author | Shin, Hye Sook Shin, Heather Hyeyoon Shudo, Yasuhiro |
author_facet | Shin, Hye Sook Shin, Heather Hyeyoon Shudo, Yasuhiro |
author_sort | Shin, Hye Sook |
collection | PubMed |
description | Establishing an appropriate disease model that mimics the complexities of human cardiovascular disease is critical for evaluating the clinical efficacy and translation success. The multifaceted and complex nature of human ischemic heart disease is difficult to recapitulate in animal models. This difficulty is often compounded by the methodological biases introduced in animal studies. Considerable variations across animal species, modifications made in surgical procedures, and inadequate randomization, sample size calculation, blinding, and heterogeneity of animal models used often produce preclinical cardiovascular research that looks promising but is irreproducible and not translatable. Moreover, many published papers are not transparent enough for other investigators to verify the feasibility of the studies and the therapeutics’ efficacy. Unfortunately, successful translation of these innovative therapies in such a closed and biased research is difficult. This review discusses some challenges in current preclinical myocardial infarction research, focusing on the following three major inhibitors for its successful translation: Inappropriate disease model, frequent modifications to surgical procedures, and insufficient reporting transparency. |
format | Online Article Text |
id | pubmed-8116580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81165802021-05-14 Current Status and Limitations of Myocardial Infarction Large Animal Models in Cardiovascular Translational Research Shin, Hye Sook Shin, Heather Hyeyoon Shudo, Yasuhiro Front Bioeng Biotechnol Bioengineering and Biotechnology Establishing an appropriate disease model that mimics the complexities of human cardiovascular disease is critical for evaluating the clinical efficacy and translation success. The multifaceted and complex nature of human ischemic heart disease is difficult to recapitulate in animal models. This difficulty is often compounded by the methodological biases introduced in animal studies. Considerable variations across animal species, modifications made in surgical procedures, and inadequate randomization, sample size calculation, blinding, and heterogeneity of animal models used often produce preclinical cardiovascular research that looks promising but is irreproducible and not translatable. Moreover, many published papers are not transparent enough for other investigators to verify the feasibility of the studies and the therapeutics’ efficacy. Unfortunately, successful translation of these innovative therapies in such a closed and biased research is difficult. This review discusses some challenges in current preclinical myocardial infarction research, focusing on the following three major inhibitors for its successful translation: Inappropriate disease model, frequent modifications to surgical procedures, and insufficient reporting transparency. Frontiers Media S.A. 2021-04-29 /pmc/articles/PMC8116580/ /pubmed/33996785 http://dx.doi.org/10.3389/fbioe.2021.673683 Text en Copyright © 2021 Shin, Shin and Shudo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Shin, Hye Sook Shin, Heather Hyeyoon Shudo, Yasuhiro Current Status and Limitations of Myocardial Infarction Large Animal Models in Cardiovascular Translational Research |
title | Current Status and Limitations of Myocardial Infarction Large Animal Models in Cardiovascular Translational Research |
title_full | Current Status and Limitations of Myocardial Infarction Large Animal Models in Cardiovascular Translational Research |
title_fullStr | Current Status and Limitations of Myocardial Infarction Large Animal Models in Cardiovascular Translational Research |
title_full_unstemmed | Current Status and Limitations of Myocardial Infarction Large Animal Models in Cardiovascular Translational Research |
title_short | Current Status and Limitations of Myocardial Infarction Large Animal Models in Cardiovascular Translational Research |
title_sort | current status and limitations of myocardial infarction large animal models in cardiovascular translational research |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116580/ https://www.ncbi.nlm.nih.gov/pubmed/33996785 http://dx.doi.org/10.3389/fbioe.2021.673683 |
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