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Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degus
It has been demonstrated that in adulthood rodents show newly born neurons in the subgranular layer (SGL) of the dentate gyrus (DG), and in the subventricular zone (SVZ). The neurons generated in the SVZ migrate through the rostral migratory stream (RMS) to the olfactory bulb. One of the markers of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116662/ https://www.ncbi.nlm.nih.gov/pubmed/33994960 http://dx.doi.org/10.3389/fnana.2021.656882 |
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author | van Groen, Thomas Kadish, Inga Popović, Natalija Caballero Bleda, María Baño-Otalora, Beatriz Rol, María Angeles Madrid, Juan Antonio Popović, Miroljub |
author_facet | van Groen, Thomas Kadish, Inga Popović, Natalija Caballero Bleda, María Baño-Otalora, Beatriz Rol, María Angeles Madrid, Juan Antonio Popović, Miroljub |
author_sort | van Groen, Thomas |
collection | PubMed |
description | It has been demonstrated that in adulthood rodents show newly born neurons in the subgranular layer (SGL) of the dentate gyrus (DG), and in the subventricular zone (SVZ). The neurons generated in the SVZ migrate through the rostral migratory stream (RMS) to the olfactory bulb. One of the markers of newly generated neurons is doublecortin (DCX). The degu similarly shows significant numbers of DCX-labeled neurons in the SGL, SVZ, and RMS. Further, most of the nuclei of these DCX-expressing neurons are also labeled by proliferating nuclear antigen (PCNA) and Ki67. Finally, whereas in rats and mice DCX-labeled neurons are predominantly present in the SGL and SVZ, with only a few DCX neurons present in piriform cortex, the degu also shows significant numbers of DCX expressing neurons in areas outside of SVZ, DG, and PC. Many areas of neocortex in degu demonstrate DCX-labeled neurons in layer II, and most of these neurons are found in the limbic cortices. The DCX-labeled cells do not stain with NeuN, indicating they are immature neurons. |
format | Online Article Text |
id | pubmed-8116662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81166622021-05-14 Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degus van Groen, Thomas Kadish, Inga Popović, Natalija Caballero Bleda, María Baño-Otalora, Beatriz Rol, María Angeles Madrid, Juan Antonio Popović, Miroljub Front Neuroanat Neuroanatomy It has been demonstrated that in adulthood rodents show newly born neurons in the subgranular layer (SGL) of the dentate gyrus (DG), and in the subventricular zone (SVZ). The neurons generated in the SVZ migrate through the rostral migratory stream (RMS) to the olfactory bulb. One of the markers of newly generated neurons is doublecortin (DCX). The degu similarly shows significant numbers of DCX-labeled neurons in the SGL, SVZ, and RMS. Further, most of the nuclei of these DCX-expressing neurons are also labeled by proliferating nuclear antigen (PCNA) and Ki67. Finally, whereas in rats and mice DCX-labeled neurons are predominantly present in the SGL and SVZ, with only a few DCX neurons present in piriform cortex, the degu also shows significant numbers of DCX expressing neurons in areas outside of SVZ, DG, and PC. Many areas of neocortex in degu demonstrate DCX-labeled neurons in layer II, and most of these neurons are found in the limbic cortices. The DCX-labeled cells do not stain with NeuN, indicating they are immature neurons. Frontiers Media S.A. 2021-04-29 /pmc/articles/PMC8116662/ /pubmed/33994960 http://dx.doi.org/10.3389/fnana.2021.656882 Text en Copyright © 2021 van Groen, Kadish, Popović, Caballero Bleda, Baño-Otalora, Rol, Madrid and Popović. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroanatomy van Groen, Thomas Kadish, Inga Popović, Natalija Caballero Bleda, María Baño-Otalora, Beatriz Rol, María Angeles Madrid, Juan Antonio Popović, Miroljub Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degus |
title | Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degus |
title_full | Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degus |
title_fullStr | Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degus |
title_full_unstemmed | Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degus |
title_short | Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degus |
title_sort | widespread doublecortin expression in the cerebral cortex of the octodon degus |
topic | Neuroanatomy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116662/ https://www.ncbi.nlm.nih.gov/pubmed/33994960 http://dx.doi.org/10.3389/fnana.2021.656882 |
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