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Adipose tissue of female Wistar rats respond to Ilex paraguariensis treatment after ovariectomy surgery
BACKGROUND AND AIM: Metabolic disturbances are known for their increasing epidemiological importance. Ilex paraguariensis presents a potential option for mitigating lipid metabolism imbalance. However, most of the literature to date has not considered sex bias. This study aimed to evaluate the effec...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116720/ https://www.ncbi.nlm.nih.gov/pubmed/34012870 http://dx.doi.org/10.1016/j.jtcme.2020.07.002 |
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author | Rocha, Débora Santos Argenta Model, Jorge Felipe Von Dentz, Maiza Maschio, Jéssica Ohlweiler, Renata Lima, Matheus Vieira Khal de Souza, Samir Sarapio, Elaine Vogt, Éverton Lopes Waszczuk, Mairique Martiny, Simony Bassani, Valquíria Linck Kucharski, Luiz Carlos |
author_facet | Rocha, Débora Santos Argenta Model, Jorge Felipe Von Dentz, Maiza Maschio, Jéssica Ohlweiler, Renata Lima, Matheus Vieira Khal de Souza, Samir Sarapio, Elaine Vogt, Éverton Lopes Waszczuk, Mairique Martiny, Simony Bassani, Valquíria Linck Kucharski, Luiz Carlos |
author_sort | Rocha, Débora Santos |
collection | PubMed |
description | BACKGROUND AND AIM: Metabolic disturbances are known for their increasing epidemiological importance. Ilex paraguariensis presents a potential option for mitigating lipid metabolism imbalance. However, most of the literature to date has not considered sex bias. This study aimed to evaluate the effect of Ilex paraguariensis on the metabolism of different adipose tissue depots in males and females. EXPERIMENTAL PROCEDURE: After ovariectomy, female Wistar rats received daily treatment with the extract (1 g/kg) for forty-five days. Biochemical serum parameters and tissue metabolism were evaluated. Oxidation, lipogenesis and lipolysis were evaluated in brown, white visceral, retroperitoneal and gonadal adipose tissues. RESULTS AND CONCLUSION: The results showed that treatment with the extract led to a reduced weight gain in ovariectomised females in comparison to control. The triglyceride concentration was decreased in males. Glucose oxidation and lipid synthesis in visceral and retroperitoneal adipose tissues were restored in ovariectomised females after treatment. The response to epinephrine decreased in visceral adipose tissue of control males; however, lipolysis in females did not respond to ovariectomy or treatment. These findings highlight the enormous potential effects of I. paraguariensis on lipid metabolism, modulating lipogenic pathways in females and lipolytic pathways in males. Furthermore, the sex approach applied in this study contributes to more effective screening of the effects of I. paraguariensis bioactive substances. |
format | Online Article Text |
id | pubmed-8116720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81167202021-05-18 Adipose tissue of female Wistar rats respond to Ilex paraguariensis treatment after ovariectomy surgery Rocha, Débora Santos Argenta Model, Jorge Felipe Von Dentz, Maiza Maschio, Jéssica Ohlweiler, Renata Lima, Matheus Vieira Khal de Souza, Samir Sarapio, Elaine Vogt, Éverton Lopes Waszczuk, Mairique Martiny, Simony Bassani, Valquíria Linck Kucharski, Luiz Carlos J Tradit Complement Med Original Article BACKGROUND AND AIM: Metabolic disturbances are known for their increasing epidemiological importance. Ilex paraguariensis presents a potential option for mitigating lipid metabolism imbalance. However, most of the literature to date has not considered sex bias. This study aimed to evaluate the effect of Ilex paraguariensis on the metabolism of different adipose tissue depots in males and females. EXPERIMENTAL PROCEDURE: After ovariectomy, female Wistar rats received daily treatment with the extract (1 g/kg) for forty-five days. Biochemical serum parameters and tissue metabolism were evaluated. Oxidation, lipogenesis and lipolysis were evaluated in brown, white visceral, retroperitoneal and gonadal adipose tissues. RESULTS AND CONCLUSION: The results showed that treatment with the extract led to a reduced weight gain in ovariectomised females in comparison to control. The triglyceride concentration was decreased in males. Glucose oxidation and lipid synthesis in visceral and retroperitoneal adipose tissues were restored in ovariectomised females after treatment. The response to epinephrine decreased in visceral adipose tissue of control males; however, lipolysis in females did not respond to ovariectomy or treatment. These findings highlight the enormous potential effects of I. paraguariensis on lipid metabolism, modulating lipogenic pathways in females and lipolytic pathways in males. Furthermore, the sex approach applied in this study contributes to more effective screening of the effects of I. paraguariensis bioactive substances. Elsevier 2020-08-01 /pmc/articles/PMC8116720/ /pubmed/34012870 http://dx.doi.org/10.1016/j.jtcme.2020.07.002 Text en © 2020 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Rocha, Débora Santos Argenta Model, Jorge Felipe Von Dentz, Maiza Maschio, Jéssica Ohlweiler, Renata Lima, Matheus Vieira Khal de Souza, Samir Sarapio, Elaine Vogt, Éverton Lopes Waszczuk, Mairique Martiny, Simony Bassani, Valquíria Linck Kucharski, Luiz Carlos Adipose tissue of female Wistar rats respond to Ilex paraguariensis treatment after ovariectomy surgery |
title | Adipose tissue of female Wistar rats respond to Ilex paraguariensis treatment after ovariectomy surgery |
title_full | Adipose tissue of female Wistar rats respond to Ilex paraguariensis treatment after ovariectomy surgery |
title_fullStr | Adipose tissue of female Wistar rats respond to Ilex paraguariensis treatment after ovariectomy surgery |
title_full_unstemmed | Adipose tissue of female Wistar rats respond to Ilex paraguariensis treatment after ovariectomy surgery |
title_short | Adipose tissue of female Wistar rats respond to Ilex paraguariensis treatment after ovariectomy surgery |
title_sort | adipose tissue of female wistar rats respond to ilex paraguariensis treatment after ovariectomy surgery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116720/ https://www.ncbi.nlm.nih.gov/pubmed/34012870 http://dx.doi.org/10.1016/j.jtcme.2020.07.002 |
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