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Targeting Sphingosine-1-Phosphate Signaling in Immune-Mediated Diseases: Beyond Multiple Sclerosis

Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in several cellular and physiological events, including lymphocyte/hematopoietic cell trafficking. An S1P gradient (low in tissues...

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Detalles Bibliográficos
Autores principales:	Pérez-Jeldres, Tamara, Alvarez-Lobos, Manuel, Rivera-Nieves, Jesús
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Leading Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116828/ https://www.ncbi.nlm.nih.gov/pubmed/33983615 http://dx.doi.org/10.1007/s40265-021-01528-8

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