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Neuroimmune Interactions and Rhythmic Regulation of Innate Lymphoid Cells

The Earth’s rotation around its axis, is one of the parameters that never changed since life emerged. Therefore, most of the organisms from the cyanobacteria to humans have conserved natural oscillations to regulate their physiology. These daily oscillations define the circadian rhythms that set the...

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Autores principales: Jacquelot, Nicolas, Belz, Gabrielle T., Seillet, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116950/
https://www.ncbi.nlm.nih.gov/pubmed/33994930
http://dx.doi.org/10.3389/fnins.2021.657081
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author Jacquelot, Nicolas
Belz, Gabrielle T.
Seillet, Cyril
author_facet Jacquelot, Nicolas
Belz, Gabrielle T.
Seillet, Cyril
author_sort Jacquelot, Nicolas
collection PubMed
description The Earth’s rotation around its axis, is one of the parameters that never changed since life emerged. Therefore, most of the organisms from the cyanobacteria to humans have conserved natural oscillations to regulate their physiology. These daily oscillations define the circadian rhythms that set the biological clock for almost all physiological processes of an organism. They allow the organisms to anticipate and respond behaviorally and physiologically to changes imposed by the day/night cycle. As other physiological systems, the immune system is also regulated by circadian rhythms and while diurnal variation in host immune responses to lethal infection have been observed for many decades, the underlying mechanisms that affect immune function and health have only just started to emerge. These oscillations are generated by the central clock in our brain, but neuroendocrine signals allow the synchronization of the clocks in peripheral tissues. In this review, we discuss how the neuroimmune interactions create a rhythmic activity of the innate lymphoid cells. We highlight how the disruption of these rhythmic regulations of immune cells can disturb homeostasis and lead to the development of chronic inflammation in murine models.
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spelling pubmed-81169502021-05-14 Neuroimmune Interactions and Rhythmic Regulation of Innate Lymphoid Cells Jacquelot, Nicolas Belz, Gabrielle T. Seillet, Cyril Front Neurosci Neuroscience The Earth’s rotation around its axis, is one of the parameters that never changed since life emerged. Therefore, most of the organisms from the cyanobacteria to humans have conserved natural oscillations to regulate their physiology. These daily oscillations define the circadian rhythms that set the biological clock for almost all physiological processes of an organism. They allow the organisms to anticipate and respond behaviorally and physiologically to changes imposed by the day/night cycle. As other physiological systems, the immune system is also regulated by circadian rhythms and while diurnal variation in host immune responses to lethal infection have been observed for many decades, the underlying mechanisms that affect immune function and health have only just started to emerge. These oscillations are generated by the central clock in our brain, but neuroendocrine signals allow the synchronization of the clocks in peripheral tissues. In this review, we discuss how the neuroimmune interactions create a rhythmic activity of the innate lymphoid cells. We highlight how the disruption of these rhythmic regulations of immune cells can disturb homeostasis and lead to the development of chronic inflammation in murine models. Frontiers Media S.A. 2021-04-29 /pmc/articles/PMC8116950/ /pubmed/33994930 http://dx.doi.org/10.3389/fnins.2021.657081 Text en Copyright © 2021 Jacquelot, Belz and Seillet. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jacquelot, Nicolas
Belz, Gabrielle T.
Seillet, Cyril
Neuroimmune Interactions and Rhythmic Regulation of Innate Lymphoid Cells
title Neuroimmune Interactions and Rhythmic Regulation of Innate Lymphoid Cells
title_full Neuroimmune Interactions and Rhythmic Regulation of Innate Lymphoid Cells
title_fullStr Neuroimmune Interactions and Rhythmic Regulation of Innate Lymphoid Cells
title_full_unstemmed Neuroimmune Interactions and Rhythmic Regulation of Innate Lymphoid Cells
title_short Neuroimmune Interactions and Rhythmic Regulation of Innate Lymphoid Cells
title_sort neuroimmune interactions and rhythmic regulation of innate lymphoid cells
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116950/
https://www.ncbi.nlm.nih.gov/pubmed/33994930
http://dx.doi.org/10.3389/fnins.2021.657081
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