Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake

The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hyp...

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Detalles Bibliográficos
Autores principales: Caruso, Vanni, Zuccarini, Mariachiara, Di Iorio, Patrizia, Muhammad, Ishaq, Ronci, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117016/
https://www.ncbi.nlm.nih.gov/pubmed/33995077
http://dx.doi.org/10.3389/fphar.2021.655989
Descripción
Sumario:The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes.

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