Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake

The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hyp...

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Autores principales: Caruso, Vanni, Zuccarini, Mariachiara, Di Iorio, Patrizia, Muhammad, Ishaq, Ronci, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117016/
https://www.ncbi.nlm.nih.gov/pubmed/33995077
http://dx.doi.org/10.3389/fphar.2021.655989
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author Caruso, Vanni
Zuccarini, Mariachiara
Di Iorio, Patrizia
Muhammad, Ishaq
Ronci, Maurizio
author_facet Caruso, Vanni
Zuccarini, Mariachiara
Di Iorio, Patrizia
Muhammad, Ishaq
Ronci, Maurizio
author_sort Caruso, Vanni
collection PubMed
description The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes.
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spelling pubmed-81170162021-05-14 Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake Caruso, Vanni Zuccarini, Mariachiara Di Iorio, Patrizia Muhammad, Ishaq Ronci, Maurizio Front Pharmacol Pharmacology The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes. Frontiers Media S.A. 2021-04-29 /pmc/articles/PMC8117016/ /pubmed/33995077 http://dx.doi.org/10.3389/fphar.2021.655989 Text en Copyright © 2021 Caruso, Zuccarini, Di Iorio, Muhammad and Ronci. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Caruso, Vanni
Zuccarini, Mariachiara
Di Iorio, Patrizia
Muhammad, Ishaq
Ronci, Maurizio
Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
title Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
title_full Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
title_fullStr Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
title_full_unstemmed Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
title_short Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
title_sort metabolic changes induced by purinergic signaling: role in food intake
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117016/
https://www.ncbi.nlm.nih.gov/pubmed/33995077
http://dx.doi.org/10.3389/fphar.2021.655989
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