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Association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an Indian population

INTRODUCTION: Sialic acid (SA) is an acetylated product of neuraminic acid. It acts as a cofactor of many cell surface receptors (e.g. insulin receptors) and is positively associated with most of the serum acute phase reactants. Sialic acid is an important component of serum, which is elevated in di...

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Autores principales: Bansal, Pankaj, Bansal, Puja, Verma, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117081/
https://www.ncbi.nlm.nih.gov/pubmed/34027208
http://dx.doi.org/10.5114/amsad.2021.105142
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author Bansal, Pankaj
Bansal, Puja
Verma, Rajesh
author_facet Bansal, Pankaj
Bansal, Puja
Verma, Rajesh
author_sort Bansal, Pankaj
collection PubMed
description INTRODUCTION: Sialic acid (SA) is an acetylated product of neuraminic acid. It acts as a cofactor of many cell surface receptors (e.g. insulin receptors) and is positively associated with most of the serum acute phase reactants. Sialic acid is an important component of serum, which is elevated in diseases such as diabetes and certain malignancies. Diabetes mellitus (DM) is associated with an increase in SA concentration along with other complications. The present study was undertaken to assess the relationship between serum SA and type 2 diabetes. MATERIAL AND METHODS: A total of 200 type 2 DM patients, 145 males and 55 females, were included in the study. Also, 100 healthy individuals served as the control group. Parameters assessed included serum SA, lipid profile, urine microalbumin, LDL-C, lipoprotein(a), and serum fibrinogen. The relationship between serum SA and diabetic complications viz retinopathy, nephropathy, and neuropathy was also assessed. RESULTS: Type 2 DM patients had significantly higher levels (p < 0.01) of SA (77.35 ±4.6 mg%) as compared to the control group (68.23 ±7.9 mg%). Increased levels of serum SA were seen in patients with diabetic nephropathy and retinopathy. No correlation was seen between serum SA and diabetic neuropathy. CONCLUSIONS: Elevated serum SA concentration is significantly related to type 2 DM and associated cardiovascular risk factors. Further study of acute-phase response markers and mediators as indicators or predictors of diabetic microvascular complications is therefore justified.
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spelling pubmed-81170812021-05-20 Association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an Indian population Bansal, Pankaj Bansal, Puja Verma, Rajesh Arch Med Sci Atheroscler Dis Clinical Research INTRODUCTION: Sialic acid (SA) is an acetylated product of neuraminic acid. It acts as a cofactor of many cell surface receptors (e.g. insulin receptors) and is positively associated with most of the serum acute phase reactants. Sialic acid is an important component of serum, which is elevated in diseases such as diabetes and certain malignancies. Diabetes mellitus (DM) is associated with an increase in SA concentration along with other complications. The present study was undertaken to assess the relationship between serum SA and type 2 diabetes. MATERIAL AND METHODS: A total of 200 type 2 DM patients, 145 males and 55 females, were included in the study. Also, 100 healthy individuals served as the control group. Parameters assessed included serum SA, lipid profile, urine microalbumin, LDL-C, lipoprotein(a), and serum fibrinogen. The relationship between serum SA and diabetic complications viz retinopathy, nephropathy, and neuropathy was also assessed. RESULTS: Type 2 DM patients had significantly higher levels (p < 0.01) of SA (77.35 ±4.6 mg%) as compared to the control group (68.23 ±7.9 mg%). Increased levels of serum SA were seen in patients with diabetic nephropathy and retinopathy. No correlation was seen between serum SA and diabetic neuropathy. CONCLUSIONS: Elevated serum SA concentration is significantly related to type 2 DM and associated cardiovascular risk factors. Further study of acute-phase response markers and mediators as indicators or predictors of diabetic microvascular complications is therefore justified. Termedia Publishing House 2021-04-09 /pmc/articles/PMC8117081/ /pubmed/34027208 http://dx.doi.org/10.5114/amsad.2021.105142 Text en Copyright: © 2021 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Bansal, Pankaj
Bansal, Puja
Verma, Rajesh
Association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an Indian population
title Association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an Indian population
title_full Association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an Indian population
title_fullStr Association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an Indian population
title_full_unstemmed Association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an Indian population
title_short Association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an Indian population
title_sort association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an indian population
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117081/
https://www.ncbi.nlm.nih.gov/pubmed/34027208
http://dx.doi.org/10.5114/amsad.2021.105142
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